Javadi Anis, Nikhbakht Mohammad Reza, Ghasemian Yadegari Javad, Rustamzadeh Auob, Mohammadi Mohsen, Shirazinejad Alireza, Azadbakht Saleh, Abdi Zahra
Department of Pharmacognosy and Pharmaceutical Biotechnology, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran.
Department of Physiology and Pharmacology, School of Medicine Medicinal Plants Research Center Yasuj, University of Medical Sciences, Yasuj, Iran.
Int J Radiat Biol. 2023;99(2):155-165. doi: 10.1080/09553002.2022.2078007. Epub 2022 May 24.
The study of the radioactive role of natural and chemical substances on human and animal studies has been the subject of research by some researchers. Therefore, the review of some of the past and current studies conducted in this field, can provide helpful information to elucidate of the importance of radioprotective components in reducing radiation exposure side effects.
The authors search for keywords including In vitro, In vivo, Radioprotective, Ionizing radiation, and Vitamin in ScienceDirect, Scopus, Pubmed, and Google Scholar databases to access previously published articles and search for more reference articles on the role of radioprotective materials from natural and chemical compounds.
Radiation exposure can produce reactive oxygen species (ROS) in the body, however most of which are eliminated by the body's natural mechanisms, but when the body's antioxidant systems do not have enough ability to neutralize free radicals, oxidative stress occurs, which causes damage to DNA and body tissues. Therefore, it is necessary use of alternative substances that reduce and inhibit free radicals.
In general, recommended that antioxidant component(s) can be protect tissue damages in humans or animals, due to the their ability to scavenge free radicals generated by ionizing radiation.
一些研究人员致力于研究天然和化学物质在人类及动物研究中的放射性作用。因此，回顾该领域过去和当前的一些研究，可为阐明辐射防护成分在减少辐射暴露副作用方面的重要性提供有用信息。
作者在ScienceDirect、Scopus、Pubmed和谷歌学术数据库中搜索包括体外、体内、辐射防护、电离辐射和维生素等关键词，以获取先前发表的文章，并搜索更多关于天然和化学化合物辐射防护材料作用的参考文献。
辐射暴露可在体内产生活性氧（ROS），然而大部分ROS会被人体自然机制清除，但当人体抗氧化系统没有足够能力中和自由基时，就会发生氧化应激，从而导致DNA和身体组织受损。因此，有必要使用能减少和抑制自由基的替代物质。
总体而言，由于抗氧化成分能够清除电离辐射产生的自由基，建议其可保护人类或动物的组织免受损伤。
