Rai Shweta, Singh Neeraj, Bhattacharya Sankha
ISF College of Pharmacy, GT Road (NH-95), Ghal Kalan, Moga, Punjab 142001, India.
Recent Pat Nanotechnol. 2022;16(1):67-89. doi: 10.2174/1872210515666210120113738.
Nanomedicine is a branch of healthcare, which has many clinical applications. Nanoscale science has to presume an attractive slot for the research in drug delivery as nanocarriers either through active or passive targeting approaches to cell-specific drug delivery. Liposomes, solid-lipid nanoparticles, dendrimers, polymeric nanoparticles, mesoporous silica nanoparticles, inorganic nanoparticles, nanotubes, quantum dots, and nanofibers are nanocarriers that are proven too smart a nano-based drug delivery system. The nanoparticulate system shows high stability, high specificity, high efficacy, and liability to form different dosages, used through different routes, as well as the ability to deliver hydrophobic as well as hydrophilic drugs. These nanoparticulate systems are showing wider applications to cure the disease through nanomedicines and biomedical applications viz. chemical and biological sensors, information storage systems, magneto-optic, optical devices, and fiber-optic systems. In this review article, the author describes various smart nano-based drug delivery systems along with their endocytic pathways used for the uptake of nanoparticles.
纳米医学是医疗保健的一个分支，有许多临床应用。纳米科学必定会在药物递送研究中占据一个有吸引力的位置，因为纳米载体可通过主动或被动靶向方法实现细胞特异性药物递送。脂质体、固体脂质纳米粒、树枝状大分子、聚合物纳米粒、介孔二氧化硅纳米粒、无机纳米粒、纳米管、量子点和纳米纤维都是纳米载体，它们被证明是非常智能的基于纳米的药物递送系统。纳米颗粒系统具有高稳定性、高特异性、高效性，并且易于形成不同剂型，可通过不同途径使用，还能够递送疏水性和亲水性药物。这些纳米颗粒系统在通过纳米医学和生物医学应用（即化学和生物传感器、信息存储系统、磁光、光学器件和光纤系统）治疗疾病方面显示出更广泛的应用。在这篇综述文章中，作者描述了各种智能的基于纳米的药物递送系统及其用于纳米颗粒摄取的内吞途径。
