Department of Medical Biotechnology, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, 88138-33435, Iran.
Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, 14115-154, Iran.
Nanomedicine (Lond). 2023 Feb;18(3):279-302. doi: 10.2217/nnm-2022-0248. Epub 2023 Apr 26.
AIDS causes increasing mortality every year. With advancements in nanomedicine, different nanomaterials (NMs) have been applied to treat AIDS and overcome its limitations. Among different NMs, nanoparticles (NPs) can act as nanocarriers due to their enhanced solubility, sustained release, targeting abilities and facilitation of drug-dose reductions. This review discusses recent advancements in therapeutics for AIDS/HIV using various NMs, mainly focused on three classifications: polymeric, liposomal and inorganic NMs. Polymeric dendrimers, polyethylenimine-NPs, poly(lactic-co-glycolic acid)-NPs, chitosan and the use of liposomal-based delivery systems and inorganic NPs, including gold and silver NPs, are explored. Recent advances, current challenges and future perspectives on the use of these NMs for better management of HIV/AIDS are also discussed.
艾滋病导致每年的死亡率不断上升。随着纳米医学的进步，不同的纳米材料（NMs）已被应用于治疗艾滋病并克服其局限性。在不同的 NMs 中，纳米颗粒（NPs）由于其增强的溶解性、持续释放、靶向能力和促进药物剂量减少，可作为纳米载体。本综述讨论了使用各种 NMs 治疗艾滋病/艾滋病病毒的最新进展，主要集中在三个分类：聚合物、脂质体和无机 NMs。探索了聚合物树突、聚乙烯亚胺-NPs、聚（乳酸-共-乙醇酸）-NPs、壳聚糖以及基于脂质体的递药系统和无机 NPs（包括金和银 NPs）的应用。还讨论了这些 NMs 在更好地管理 HIV/AIDS 方面的最新进展、当前挑战和未来展望。
