Yu M C, Mo C C, Chong W X, Yeh F S, Henderson B E
Department of Preventive Medicine, University of Southern California School of Medicine, Los Angeles 90033.
Cancer Res. 1988 Apr 1;48(7):1954-9.
One hundred twenty-eight mothers of nasopharyngeal carcinoma (NPC) cases under age 45 in Yulin Prefecture, China and 174 mothers of population controls were interviewed as part of an epidemiological study to examine childhood exposures in relation to the development of NPC. Exposure before age 2 years to a number of fermented foods was a risk factor for NPC. During weaning, intake of salted fish [relative risk (RR) = 2.6, one-sided P (P) = 0.01], salted duck eggs (RR = 5.0, P = 0.03), salted mustard green (RR = 5.4, P = 0.03), and chung choi (RR = 2.0), P = 0.003), a kind of salted root, was significantly related to an increased risk of NPC. Between ages 1 and 2 years, intake frequency of dried fish [P for linear trend test (linear trend P) = 0.002], fermented black bean paste (linear trend P = 0.0009), and fermented soy bean paste (linear trend P = 0.007) was also positively associated with NPC. A multivariate analysis of these different foods showed all except fermented black bean paste to be independently related to NPC.
作为一项关于儿童期暴露与鼻咽癌发生关系的流行病学研究的一部分，对中国玉林地区128名45岁以下鼻咽癌患者的母亲和174名对照人群的母亲进行了访谈。2岁前接触多种发酵食品是鼻咽癌的一个危险因素。断奶期间，食用咸鱼（相对危险度RR = 2.6，单侧P值P = 0.01）、咸鸭蛋（RR = 5.0，P = 0.03）、腌芥菜（RR = 5.4，P = 0.03）和一种腌根菜冲菜（RR = 2.0，P = 0.003）均与鼻咽癌风险增加显著相关。1至2岁期间，食用鱼干（线性趋势检验P值，即线性趋势P = 0.002）、豆豉酱（线性趋势P = 0.0009）和豆瓣酱（线性趋势P = 0.007）的频率也与鼻咽癌呈正相关。对这些不同食物的多变量分析显示，除豆豉酱外，其他食物均与鼻咽癌独立相关。
