Lyu Yun-Hong, Lin Chu-Yang, Xie Shang-Hang, Li Tong, Liu Qing, Ling Wei, Lu Yu-Qiang, Cao Su-Mei, Lin Ai-Hua
School of Public Health, Sun Yat-Sen University, Guangzhou, China.
Department of Cancer Prevention Center, Sun Yat-Sen University Cancer Center, Guangzhou, China.
Front Oncol. 2021 Oct 21;11:715242. doi: 10.3389/fonc.2021.715242. eCollection 2021.
Prospective evidence for herbal diet and nasopharyngeal carcinoma (NPC) development is absent. We therefore evaluated the associations of herbal soup and herbal tea with NPC in a prospective cohort study in southern China.
Based on an NPC screening cohort established in 2008-2015, information on herbal diet consumption, potential confounding factors, and Epstein-Barr virus (EBV) antibody levels were collected from 10,179 individuals aged 30-69 years in Sihui city, southern China. Cox regression models were performed to examine herbal diet with NPC risk, and logistic regression models were used to examine herbal diet with EBV reactivation.
During a median of 7.54 years of follow-up, 69 participants developed NPC. Herbal soup consumption was associated with decreased NPC risk, with HRs of 0.31 (95% confidence interval (CI): 0.15-0.62) for the highest intake frequency and 0.29 (95% CI: 0.16-0.51) for a longer duration. However, herbal tea was not significantly associated. Moreover, we identified herbal soup was inversely associated with EBV seropositivity among all the participants at baseline, with the adjusted ORs being 0.78 (95% CI: 0.65-0.93) for immunoglobulin A antibodies against EBV capsid antigens (VCA-IgA) and 0.76 (95% CI: 0.64-0.91) for nuclear antigen 1 (EBNA1-IgA) in those with the highest frequency and 0.70 (95% CI: 0.59-0.84) for VCA-IgA and 0.64 (95% CI: 0.54-0.77) for EBNA1-IgA in those with the longer duration. Inverse associations were also observed in non-NPC individuals.
With inhibition of EBV reactivation by plants, herbal soup could significantly decrease the risk of NPC in endemic areas.
目前尚无关于草药饮食与鼻咽癌（NPC）发生的前瞻性证据。因此，我们在中国南方的一项前瞻性队列研究中评估了草药汤和凉茶与NPC的关联。
基于2008 - 2015年建立的NPC筛查队列，收集了中国南方四会市10179名30 - 69岁个体的草药饮食消费信息、潜在混杂因素以及 Epstein - Barr病毒（EBV）抗体水平。采用Cox回归模型检验草药饮食与NPC风险的关系，采用逻辑回归模型检验草药饮食与EBV再激活的关系。
在中位随访7.54年期间，69名参与者发生了NPC。饮用草药汤与NPC风险降低相关，最高摄入频率组的风险比（HR）为0.31（95%置信区间（CI）：0.15 - 0.62），饮用时间较长组的HR为0.29（95% CI：0.16 - 0.51）。然而，凉茶与NPC风险无显著关联。此外，我们发现草药汤与基线时所有参与者的EBV血清阳性呈负相关，在饮用频率最高的人群中，针对EBV衣壳抗原的免疫球蛋白A抗体（VCA - IgA）的调整比值比（OR）为0.78（95% CI：0.65 - 0.93），核抗原1（EBNA1 - IgA）的调整OR为0.76（95% CI：0.64 - 0.91）；在饮用时间较长的人群中，VCA - IgA的调整OR为0.70（95% CI：0.59 - 0.84），EBNA1 - IgA的调整OR为0.64（95% CI：0.54 - 0.77）。在非NPC个体中也观察到了负相关。
通过植物对EBV再激活的抑制作用，草药汤可显著降低流行地区NPC的风险。
