Dehghani Tafti Arefeh, Mirjalili Bi Bi Fatemeh, Bamoniri Abdolhamid, Salehi Naeimeh
Department of Chemistry, College of Science, Yazd University, P.O.Box 89195-741, Yazd, I.R. of Iran.
Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I.R. of Iran.
BMC Chem. 2021 Jan 25;15(1):6. doi: 10.1186/s13065-021-00734-5.
Nano-eggshell/Ti(IV) as a novel naturally based catalyst was prepared, characterized and applied for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives. The characterization of nano-eggshell/Ti(IV) was performed using Fourier Transform Infrared spectroscopy, X-ray Diffraction, Field Emission Scanning Electron Microscopy, Energy-Dispersive X-ray Spectroscopy, and Thermo Gravimetric Analysis. Dihydropyrano[2,3-c]pyrazoles were synthesized in the presence of nano-eggshell/Ti(IV) via a four component reaction of aldehydes, ethyl acetoacetate, malononitrile and hydrazine hydrate at room temperature under solvent free conditions. The principal affairs of this procedure are mild condition, short reaction times, easy work-up, high yields, reusability of the catalyst and the absence of toxic organic solvents.
制备了纳米蛋壳/Ti(IV)作为一种新型的天然基催化剂，对其进行了表征，并将其应用于二氢吡喃并[2,3-c]吡唑衍生物的合成。使用傅里叶变换红外光谱、X射线衍射、场发射扫描电子显微镜、能量色散X射线光谱和热重分析对纳米蛋壳/Ti(IV)进行了表征。在纳米蛋壳/Ti(IV)存在下，通过醛、乙酰乙酸乙酯、丙二腈和水合肼在室温无溶剂条件下的四组分反应合成了二氢吡喃并[2,3-c]吡唑。该方法的主要优点是条件温和、反应时间短、后处理容易、产率高、催化剂可重复使用且不存在有毒有机溶剂。
