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哌仑西平治疗消化性溃疡的经验(作者译)

[Experiences with Pirenzepin in the therapy of peptic ulcers (author's transl)].

作者信息

Wegmann R, Bliem J, Löffelmann K, Lujf A

出版信息

Wien Med Wochenschr. 1979 Oct 10;129(18):513-6.

PMID:524896
Abstract

21 patients with peptic ulcers were treated with 2X25 mg Pirenzepin daily. A decrease in basal and Pentagastrin-stimulated HCl-secretion was found. Patients with duodenal ulcers (n = 12) or gastric ulcers (n = 9) became painless within 6 to 11 days. 18 ulcers healed under treatment with Pirenzepin. Patients with duodenal ulcer showed recovery sooner than patients with gastric ulcer. One year later recurrent ulcers were observed in 4 cases. Side-effects of Pirenzepin did not occur.

摘要

21例消化性溃疡患者每日服用2×25毫克哌仑西平进行治疗。发现基础胃酸分泌和五肽胃泌素刺激的盐酸分泌均减少。十二指肠溃疡患者(n = 12)和胃溃疡患者(n = 9)在6至11天内疼痛消失。18例溃疡在哌仑西平治疗下愈合。十二指肠溃疡患者比胃溃疡患者恢复得更快。一年后,4例出现复发性溃疡。未出现哌仑西平的副作用。

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引用本文的文献

1
Pirenzepine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in peptic ulcer disease and other allied diseases.哌仑西平。其药效学和药代动力学特性以及在消化性溃疡疾病和其他相关疾病中的治疗效果综述。
Drugs. 1985 Aug;30(2):85-126. doi: 10.2165/00003495-198530020-00001.