Morelli A, Pelli A, Narducci F, Spadacini A
Scand J Gastroenterol Suppl. 1979;57:51-5.
The effectiveness of pirenzepine in the treatment of gastric ulcer was assessed in a double-blind 6 weeks' clinical trial in comparison with placebo. After 2 weeks of treatment 1 patient in each group showed a complete healing of gastric ulcer. After 6 weeks of treatment 9 out of 10 patients in the pirenzepine group (90%) and 4 out of 10 patients in the placebo group (40%) healed (P less than 0.05). The relief of ulcer symptoms was significantly better in the pirenzepine group than in the placebo group. From the second week on, the pirenzepine-treated patients stopped taking antacid while placebo-treated patients went on taking it (P less than 0.02). The results of this study demonstrated that pirenzepine promotes gastric ulcer healing and induces a rapid regression of ulcer symptoms.
在一项为期6周的双盲临床试验中，将哌仑西平与安慰剂对比，评估其治疗胃溃疡的疗效。治疗2周后，每组各有1例患者胃溃疡完全愈合。治疗6周后，哌仑西平组10例患者中有9例（90%）愈合，安慰剂组10例患者中有4例（40%）愈合（P<0.05）。哌仑西平组溃疡症状的缓解明显优于安慰剂组。从第二周起，接受哌仑西平治疗的患者停止服用抗酸剂，而接受安慰剂治疗的患者继续服用（P<0.02）。本研究结果表明，哌仑西平可促进胃溃疡愈合，并能迅速缓解溃疡症状。
