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针对衣原体传播的定制行为干预措施的影响建模。

Modelling the impact of tailored behavioural interventions on chlamydia transmission.

机构信息

Center for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA, Bilthoven, The Netherlands.

Department of Interdisciplinary Social Science, Faculty of Social and Behavioural Sciences, Utrecht University, Utrecht, The Netherlands.

出版信息

Sci Rep. 2021 Jan 25;11(1):2148. doi: 10.1038/s41598-021-81675-w.

DOI:10.1038/s41598-021-81675-w
PMID:33495513
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7835240/
Abstract

Behavioural interventions tailored to psychological characteristics of an individual can effectively achieve risk-reducing behaviour. The impact of tailored interventions on population-level chlamydia prevalence is unknown. We aimed to assess the impact on overall chlamydia prevalence five years after the introduction of an intervention aimed at increasing self-efficacy, social norms, attitudes and intentions towards condom use (i.e., condom intervention), and an intervention aimed at increasing health goals and decreasing impulsiveness (i.e., impulsiveness intervention). A pair model, informed by longitudinal psychological and behavioural data of young heterosexuals visiting sexual health centers, with susceptible-infected-susceptible structure was developed. The intervention effect was defined as an increased proportion of each subgroup moving to the desired subgroup (i.e., lower risk subgroup). Interventions tailored to subgroup-specific characteristics, assuming differential intervention effects in each subgroup, more effectively reduced overall chlamydia prevalence compared to non-tailored interventions. The most effective intervention was the tailored condom intervention, which was assumed to result in a relative reduction in chlamydia prevalence of 18% versus 12% in the non-tailored scenario. Thus, it is important to assess multiple psychological and behavioural characteristics of individuals. Tailored interventions may be more successful in achieving risk-reducing behaviour, and consequently, reduce chlamydia prevalence more effectively.

摘要

针对个体心理特征量身定制的行为干预措施可以有效地实现降低风险的行为。针对人群层面衣原体流行率的量身定制干预措施的影响尚不清楚。我们旨在评估在引入旨在提高避孕套使用的自我效能、社会规范、态度和意愿(即避孕套干预)以及旨在提高健康目标和减少冲动性(即冲动性干预)的干预措施五年后对总体衣原体流行率的影响。基于年轻异性恋者访问性健康中心的纵向心理和行为数据,采用易感性-感染-易感性结构的配对模型进行了研究。干预效果定义为每个亚组向期望亚组(即低风险亚组)移动的比例增加。与非量身定制的干预相比,针对特定亚组特征量身定制的干预措施,假设每个亚组的干预效果不同,更有效地降低了总体衣原体流行率。最有效的干预措施是量身定制的避孕套干预,与非量身定制的方案相比,预计会使衣原体流行率相对降低 18%,而非 12%。因此,评估个人的多种心理和行为特征很重要。量身定制的干预措施可能更成功地实现降低风险的行为,从而更有效地降低衣原体流行率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fc0/7835240/2d069f30e2dd/41598_2021_81675_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fc0/7835240/fddecae7c4df/41598_2021_81675_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fc0/7835240/3660406ed819/41598_2021_81675_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fc0/7835240/c46b08470a2b/41598_2021_81675_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fc0/7835240/2d069f30e2dd/41598_2021_81675_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fc0/7835240/fddecae7c4df/41598_2021_81675_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fc0/7835240/3660406ed819/41598_2021_81675_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fc0/7835240/c46b08470a2b/41598_2021_81675_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fc0/7835240/2d069f30e2dd/41598_2021_81675_Fig4_HTML.jpg

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本文引用的文献

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Prev Med. 2020 Oct;139:106200. doi: 10.1016/j.ypmed.2020.106200. Epub 2020 Jul 11.
2
Longitudinal Patterns of Sexually Transmitted Infection Risk Based on Psychological Characteristics and Sexual Behavior in Heterosexual Sexually Transmitted Infection Clinic Visitors.基于心理特征和性行为的异性性传播感染门诊就诊者的性传播感染风险的纵向模式。
Sex Transm Dis. 2020 Mar;47(3):171-176. doi: 10.1097/OLQ.0000000000001110.
3
Healthcare provider and service user perspectives on STI risk reduction interventions for young people and MSM in the UK.
英国医疗保健提供者和服务使用者对年轻人和男男性行为者性病风险降低干预措施的看法。
Sex Transm Infect. 2020 Feb;96(1):26-32. doi: 10.1136/sextrans-2018-053903. Epub 2019 Jul 26.
4
A Multidimensional Approach to Assessing Infectious Disease Risk: Identifying Risk Classes Based on Psychological Characteristics.多维方法评估传染病风险:基于心理特征确定风险类别。
Am J Epidemiol. 2019 Sep 1;188(9):1705-1712. doi: 10.1093/aje/kwz140.
5
Impact of sexual trajectories of men who have sex with men on the reduction in HIV transmission by pre-exposure prophylaxis.男男性行为者的性轨迹对暴露前预防降低 HIV 传播的影响。
Epidemics. 2019 Sep;28:100337. doi: 10.1016/j.epidem.2019.03.003. Epub 2019 Mar 14.
6
Discrepancies between observed data and predictions from mathematical modelling of the impact of screening interventions on Chlamydia trachomatis prevalence.观察数据与基于数学模型的筛查干预对沙眼衣原体流行率影响的预测之间的差异。
Sci Rep. 2019 May 17;9(1):7547. doi: 10.1038/s41598-019-44003-x.
7
Relation between infection and pelvic inflammatory disease, ectopic pregnancy and tubal factor infertility in a Dutch cohort of women previously tested for chlamydia in a chlamydia screening trial.在一项衣原体筛查试验中,对荷兰队列中的妇女进行了衣原体检测,本研究旨在探讨感染与盆腔炎、宫外孕和输卵管性不孕之间的关系。
Sex Transm Infect. 2019 Jun;95(4):300-306. doi: 10.1136/sextrans-2018-053778. Epub 2019 Jan 3.
8
Study protocol of the iMPaCT project: a longitudinal cohort study assessing psychological determinants, sexual behaviour and chlamydia (re)infections in heterosexual STI clinic visitors.iMPaCT 项目研究方案:一项评估异性性传播感染门诊就诊者心理决定因素、性行为和衣原体(再)感染的纵向队列研究。
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National prevalence estimates of chlamydia and gonorrhoea in the Netherlands.荷兰衣原体和淋病的全国流行率估计。
Sex Transm Infect. 2019 Feb;95(1):53-59. doi: 10.1136/sextrans-2017-053478. Epub 2018 Jun 20.
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Double trouble: modelling the impact of low risk perception and high-risk sexual behaviour on chlamydia transmission.双重麻烦:建模低风险感知和高风险性行为对衣原体传播的影响。
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