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[首批经典方剂炮制特点浅探及文献考证建议]

[Brief study on processing characteristics of first batch of classical prescriptions and suggestions on textual research].

作者信息

Wang Yun, Zheng Ying-Hao, Zhang Cun

机构信息

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2020 Dec;45(23):5631-5638. doi: 10.19540/j.cnki.cjcmm.20200910.301.

Abstract

As an important treasure for the research and development of new Chinese medicines, the classical prescriptions have a long medical history in China and are the summary of the clinical experience of the medical experts in the past dynasties. To support the research and development of classical prescriptions,relevant encouraging policies were issued by the state and relevant administrative departments. It is one of the key problems in the development process of classical prescriptions to verify and determine the processing methods of prescription herbal drugs. At present, there is no consensus or standard on such problems of classical prescriptions. In this paper, we sorted out and analyzed the related content of the herb processing for classical prescriptions, summarized the characteristics of the processing methods in the Catalogue of classical prescriptions(First Batch) and the problems faced in the textual research, and put forward some suggestions on the processing and textual research, including four research strategies: sorting out the mainstream methods for herbs in various periods of classical prescriptions, clarifying histological changes in the processing methods, determining the processing methods based on the drug processing characteristics, determining the processing methods based on the processing functions and identifying the processing methods according to the clinical efficacy and indication, so as to provide ideas and references for the research of processing methods involved in classical prescriptions.

摘要

作为中药新药研发的重要宝库,经典名方在中国有着悠久的医药历史,是历代医学专家临床经验的总结。为支持经典名方的研发,国家及相关行政部门出台了相关鼓励政策。验证和确定方剂中药材的炮制方法是经典名方开发过程中的关键问题之一。目前,对于经典名方的此类问题尚无共识或标准。本文梳理分析了经典名方中药炮制的相关内容,总结了《古代经典名方目录(第一批)》中炮制方法的特点及考证中面临的问题,并对炮制及考证提出了一些建议,包括四种研究策略:梳理经典名方各时期药材的主流炮制方法、阐明炮制方法中的组织学变化、基于药物炮制特性确定炮制方法、基于炮制作用确定炮制方法以及根据临床疗效和适应证鉴别炮制方法,以期为经典名方涉及的炮制方法研究提供思路和参考。

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