De Neve W, Van der Elst J, Geerts F, Van Loon R, De Clerck V, Storme G
Department of Radiotherapy, Vrije Universiteit Brussel, Belgium.
Clin Exp Metastasis. 1988 May-Jun;6(3):213-9. doi: 10.1007/BF01782481.
The effect of ambient temperature was analysed on the behaviour of MO4 cells which are malignant, invasive and metastasizing C3H mouse fibroblastic cells when implanted in the tail of the syngeneic animal. Raising the ambient temperature to 28 degrees C increases growth of the primary tumour, incidence of metastases and shortens survival. Lowering the ambient temperature to 13 degrees C prevents all these phenomena. Measurements at the implantation site show that the temperature of the tail remains in a range +/- 2-3 degrees C in accordance with the environment. From these results we conclude that room temperature may be important when experiments are performed in vivo.
分析了环境温度对MO4细胞行为的影响，MO4细胞是恶性、具有侵袭性和转移性的C3H小鼠成纤维细胞，将其植入同基因动物的尾巴中。将环境温度提高到28摄氏度会增加原发性肿瘤的生长、转移发生率并缩短生存期。将环境温度降低到13摄氏度可防止所有这些现象。在植入部位的测量表明，尾巴的温度根据环境保持在±2 - 3摄氏度的范围内。从这些结果我们得出结论，在进行体内实验时室温可能很重要。
