Zavanella T
Cancer Lett. 1985 Jun;27(2):171-9. doi: 10.1016/0304-3835(85)90106-5.
The influence of environmental temperature on tumor growth in newts injected subcutaneously with melanoma cell suspensions was studied. No signs of tumor growth were observed in animals kept at 4 degrees C, even after 1 year, whereas animals kept at 30 degrees C died after 2-4 weeks of widespread metastatic disease. In newts kept at both 17 degrees C and 27 degrees C and killed 25 days after the tumor grafting, blood-borne tumor emboli were often found. However, widespread metastases were present only in those kept at 27 degrees C. These findings suggest that by operating at a proper environmental temperature to slow down tumor growth, melanoma of the crested newt could serve as a useful experimental model for study of the different steps of metastatic spread.
研究了环境温度对皮下注射黑色素瘤细胞悬液的蝾螈肿瘤生长的影响。饲养在4摄氏度的动物即使在1年后也未观察到肿瘤生长迹象，而饲养在30摄氏度的动物在广泛转移性疾病发生2 - 4周后死亡。在肿瘤移植后25天处死的饲养在17摄氏度和27摄氏度的蝾螈中，经常发现血源性肿瘤栓子。然而，只有饲养在27摄氏度的蝾螈出现了广泛转移。这些发现表明，通过在适宜的环境温度下操作以减缓肿瘤生长，东方蝾螈黑色素瘤可作为研究转移扩散不同步骤的有用实验模型。
