Bodla Shourya, Jain Prince, Khanra Anwesha, Sharma Chhavi, Jyoti Anupam, Purohit Shiv Dutt, Singh Hemant, Singh Abhijeet, Saxena Juhi
Department of Biotechnology, Parul Institute of TechnologyParul University Vadodara 391760 India.
Department of Mechatronics Engineering, Parul Institute of TechnologyParul University Vadodara 391760 India.
IEEE Open J Eng Med Biol. 2025 Apr 18;6:450-458. doi: 10.1109/OJEMB.2025.3562382. eCollection 2025.
Wound healing process is associated with multifaceted complications and is a functional way to advance the therapeutic process. Polymeric biomaterials exhibit structural mimicry with the extracellular matrix of the tissue to be regenerated and they also avoid chronic inflammation and immunological responses. Chitosan, a biopolymer demonstrates exceptional healing properties because of its biocompatibility, biodegradability, antimicrobial nature and affinity for biomolecules. Biomaterials consisting of chitosan along with herbal extracts could be ideal for wound healing. Click chemistry can provide one of the best ways to combine these bio-actives with chitosan. Advancing wound healing strategies with artificial intelligence /machine learning approaches can be employed further to boost the clinical efficacies of bioactive-loaded chitosan composite hydrogels. This review article investigates functionalized wound dressings with special emphasis on chitosan-based hydrogels, their effects on wound healing, and advanced approaches to increase hydrogel benefits by adding bioactive substances to form nanocomposites.
伤口愈合过程与多方面的并发症相关，并且是推进治疗过程的一种功能性方式。聚合物生物材料与待再生组织的细胞外基质具有结构相似性，并且它们还能避免慢性炎症和免疫反应。壳聚糖作为一种生物聚合物，因其生物相容性、可生物降解性、抗菌特性以及对生物分子的亲和力而展现出卓越的愈合特性。由壳聚糖与草药提取物组成的生物材料可能是伤口愈合的理想选择。点击化学可以提供将这些生物活性物质与壳聚糖相结合的最佳方法之一。采用人工智能/机器学习方法推进伤口愈合策略可进一步提高负载生物活性物质的壳聚糖复合水凝胶的临床疗效。这篇综述文章研究了功能化伤口敷料，特别强调了基于壳聚糖的水凝胶、它们对伤口愈合的影响，以及通过添加生物活性物质形成纳米复合材料来增加水凝胶益处的先进方法。
