在固定剂量控制性卵巢刺激的受精程序患者中，抗苗勒管激素水平和窦卵泡计数与卵母细胞数量的相关性
Correlation of Anti-Mullerian Hormone Level and Antral Follicle Count with Oocyte Number in A Fixed-Dose Controlled Ovarian Hyperstimulation of Patients of Fertilization Program.
作者信息
Permadi Wiryawan, Wahyu Ferdian Mohammad, Tjahyadi Dian, Ardhana Iswari Wulan, Djuwantono Tono
机构信息
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran - Dr Hasan Sadikin Hospital (RSHS), Bandung, Indonesia. Email:
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran - Dr Hasan Sadikin Hospital (RSHS), Bandung, Indonesia.
出版信息
Int J Fertil Steril. 2021 Jan;15(1):40-43. doi: 10.22074/ijfs.2021.6238. Epub 2021 Jan 19.
BACKGROUND
This study was conducted to determine the correlation of anti-Mullerian hormone (AMH) level and antral follicle count (AFC) with oocyte count in women who had received controlled ovarian hyperstimulation in an fertilization (IVF) program.
MATERIALS AND METHODS
We retrospectively gathered the data of 42 patients who underwent IVF during 2005-2017 at Aster Clinic in Dr. Hasan Sadikin Hospital and Bandung Fertility Center Limijati Hospital, Indonesia. Details of the subjects such as identity, characteristics, history of illness, history of previous therapy, levels of ovarian reserve markers examined (AFC and AMH), follicle-stimulating hormone (FSH) dose given, and number of oocytes produced were recorded.
RESULTS
A significant positive correlation between AMH (P≤0.001, r=0.530), AFC (P≤0.001, r=0.687), and AMHAFC combination (P≤0.001, r=0.652), and the number of oocytes was found at the FSH dose of 225 IU.
CONCLUSION
AFC and AMH are able to reliably predict ovarian response to FSH.
背景
本研究旨在确定在体外受精（IVF）程序中接受控制性卵巢刺激的女性中，抗苗勒管激素（AMH）水平和窦卵泡计数（AFC）与卵母细胞数量之间的相关性。
材料与方法
我们回顾性收集了2005年至2017年期间在印度尼西亚万隆哈桑·萨迪金博士医院的Aster诊所和Limijati医院万隆生育中心接受IVF的42例患者的数据。记录了受试者的详细信息，如身份、特征、病史、既往治疗史、检查的卵巢储备标志物水平（AFC和AMH）、给予的促卵泡激素（FSH）剂量以及产生的卵母细胞数量。
结果
在促卵泡激素（FSH）剂量为225国际单位时，发现AMH（P≤0.001，r = 0.530）、AFC（P≤0.001，r = 0.687）以及AMH与AFC的组合（P≤0.001，r = 0.652）与卵母细胞数量之间存在显著正相关。
结论
AFC和AMH能够可靠地预测卵巢对FSH的反应。
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