核变形让细胞能够衡量它们的物理约束。
Nuclear Deformation Lets Cells Gauge Their Physical Confinement.
机构信息
Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA; Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA.
Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA; Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA.
出版信息
Dev Cell. 2021 Jan 25;56(2):156-158. doi: 10.1016/j.devcel.2021.01.002.
How cells sense their physical microenvironment remains incompletely understood. In two recent Science articles, Lomakin et al. (2020) and Venturini et al. (2020) demonstrate that progressive nuclear deformation associated with cellular confinement triggers intracellular events that promote cell contractility and migration, revealing the nucleus to serve as a central mechanosensor.
细胞如何感知其物理微环境仍不完全清楚。在最近的两篇《科学》杂志论文中，Lomakin 等人（2020 年）和 Venturini 等人（2020 年）表明，与细胞受限相关的核渐进性变形会引发细胞内事件，促进细胞收缩和迁移，这表明核可作为中央机械感受器。
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