Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 812, Taiwan.
Int J Environ Res Public Health. 2021 Jan 20;18(3):857. doi: 10.3390/ijerph18030857.
The incidence of is increasing worldwide, and it is strongly associated with metabolic syndrome (MetS) and some obesity-related indices. However, few studies have investigated gender differences in these associations. The aim of this study was to investigate associations among MetS and various obesity-related indices with NAFLD, and also look at gender differences in these associations. We enrolled participants who completed a health survey in southern Taiwan. MetS was defined according to the Adult Treatment Panel III for Asians, and the following obesity-related indices were calculated: body mass index (BMI), waist-to-height ratio (WHtR), waist-hip ratio (WHR), lipid accumulation product (LAP), body roundness index (BRI), conicity index (CI), visceral adiposity index (VAI), body adiposity index (BAI), abdominal volume index (AVI), triglyceride-glucose (TyG) index, and hepatic steatosis index (HSI). NAFLD was diagnosed when hepatic steatosis was noted on a liver ultrasound. A total of 1969 (764 men and 1205 women) participants were enrolled. Multivariable analysis showed that both male and female participants with MetS, high BMI, high WHtR, high WHR, high LAP, high BRI, high CI, high VAI, high BAI, high AVI, high TyG index, and high HSI were significantly associated with NAFLD. In addition, the interactions between MetS and gender, WHR and gender, LAP and gender, and TyG index and gender on NAFLD were statistically significant. Among these obesity-related indices, HSI and LAP had the greatest area under the curve in both men and women. Furthermore, stepwise increases in the number of MetS components and the values of indices corresponding to the severity of NAFLD were noted. In conclusion, our results demonstrated significant relationships between MetS and obesity-related indices with NAFLD, and also stepwise increases in the number of MetS components and the values of indices with the severity of NAFLD. MetS, WHR, LAP, and TyG index were associated with NAFLD more obviously in women than in men.
的发病率在全球范围内正在上升，并且与代谢综合征（MetS）和一些肥胖相关指标密切相关。然而，很少有研究调查这些关联在性别方面的差异。本研究旨在探讨 MetS 与各种肥胖相关指标与非酒精性脂肪性肝病（NAFLD）之间的关联，并观察这些关联在性别方面的差异。我们招募了在台湾南部完成健康调查的参与者。MetS 根据亚洲成人治疗小组 III 进行定义，并且计算了以下肥胖相关指标：体重指数（BMI）、腰高比（WHtR）、腰臀比（WHR）、脂肪堆积产物（LAP）、身体圆形指数（BRI）、锥度指数（CI）、内脏脂肪指数（VAI）、身体脂肪指数（BAI）、腹部容量指数（AVI）、甘油三酯-葡萄糖（TyG）指数和肝脂肪指数（HSI）。当肝脏超声检查发现肝脂肪变性时，诊断为 NAFLD。共纳入 1969 名（764 名男性和 1205 名女性）参与者。多变量分析显示，患有 MetS、高 BMI、高 WHtR、高 WHR、高 LAP、高 BRI、高 CI、高 VAI、高 BAI、高 AVI、高 TyG 指数和高 HSI 的男性和女性参与者均与 NAFLD 显著相关。此外，MetS 与性别、WHR 与性别、LAP 与性别以及 TyG 指数与性别之间的相互作用对 NAFLD 有统计学意义。在这些肥胖相关指标中，HSI 和 LAP 在男性和女性中具有最大的曲线下面积。此外，随着 MetS 成分数量的逐步增加以及与 NAFLD 严重程度相对应的指标值的增加，观察到 NAFLD 的发生率逐步增加。总之，我们的结果表明 MetS 与肥胖相关指标与 NAFLD 之间存在显著关系，并且随着 MetS 成分数量和与 NAFLD 严重程度相对应的指标值的逐步增加，NAFLD 的发生率也在逐步增加。MetS、WHR、LAP 和 TyG 指数与女性的 NAFLD 相关性比男性更明显。
