以及作为帕金森病风险因素的多态性。
and Polymorphisms as Risk Factors for Parkinson's Disease.
作者信息
Siokas Vasileios, Aloizou Athina-Maria, Tsouris Zisis, Liampas Ioannis, Liakos Panagiotis, Calina Daniela, Docea Anca Oana, Tsatsakis Aristidis, Bogdanos Dimitrios P, Hadjigeorgiou Georgios M, Dardiotis Efthimios
机构信息
Laboratory of Neurogenetics, Department of Neurology, University Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41110 Larissa, Greece.
Laboratory of Biochemistry, Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece.
出版信息
J Clin Med. 2021 Jan 20;10(3):381. doi: 10.3390/jcm10030381.
BACKGROUND
Parkinson's disease (PD) is the second commonest neurodegenerative disease. The genetic basis of PD is indisputable. Both and have been linked to PD, to some extent, but the exact role of those polymorphisms in PD remains controversial.
OBJECTIVE
We assessed the role of and on PD risk.
METHODS
We genotyped 358 patients with PD and 358 healthy controls for and . We also merged and meta-analyzed our data with data from previous studies, regarding these two polymorphisms and PD.
RESULTS
No significant association with PD was revealed ( > 0.05), for either or , in any of the examined genetic model of inheritance. In addition, results from meta-analyses yield negative results.
CONCLUSIONS
Based on our analyses, it appears rather unlikely that or is among the major risk factors for PD, at least in Greek patients with PD.
背景
帕金森病（PD）是第二常见的神经退行性疾病。PD的遗传基础是无可争议的。[此处原文缺失具体基因名称]在一定程度上都与PD有关联，但这些多态性在PD中的确切作用仍存在争议。
目的
我们评估了[此处原文缺失具体基因名称]对PD风险的作用。
方法
我们对358例PD患者和358例健康对照进行了[此处原文缺失具体基因名称]的基因分型。我们还将我们的数据与之前关于这两种多态性和PD的研究数据进行了合并和荟萃分析。
结果
在任何所检测的遗传遗传模型中，[此处原文缺失具体基因名称]与PD均未显示出显著关联（P>0.05）。此外，荟萃分析结果为阴性。
结论
基于我们的分析，[此处原文缺失具体基因名称]似乎不太可能是PD的主要危险因素之一，至少在希腊PD患者中是这样。
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