del Piano M, Nicosia R, Sessa R, Grippaudo G, Lolli R, Monaco B
IV Chair of Microbiology, University La Sapienza, Rome, Italy.
Chemotherapy. 1988;34(1):13-7. doi: 10.1159/000238541.
21 patients, whose age ranged from 17 to 60 years and who had not been previously treated with antibiotics or other drugs, received bacampicillin as a perioperative prophylaxis for minor operations in the oral cavity. Four oral doses of bacampicillin were administered: each dose of 800 mg every 12 h, and the last dose was administered 2 h before surgery. To assess bacampicillin serum concentrations two blood samples were collected from each patient: the first sample was obtained 1 h before surgery and the second one during surgery. Together with the second blood sample, small quantities of gingiva and bone were obtained from each patient to also assess the antibiotic concentrations in these tissues (microbiological method). The results show that bacampicillin reaches high concentrations in both the blood and tissues studied by us, and that a direct correspondence exists between blood and gingival and bone tissue concentrations. Furthermore, it should be noted that no postoperative infections developed in our patients. These results lead to the conclusion that bacampicillin appears to be a suitable drug in the therapy of dental infections.
21名年龄在17至60岁之间、此前未接受过抗生素或其他药物治疗的患者，接受了巴卡西林作为口腔小手术的围手术期预防用药。给予巴卡西林口服4剂：每12小时服用800毫克，最后一剂在手术前2小时服用。为评估巴卡西林的血清浓度，从每位患者采集两份血样：第一份样本在手术前1小时采集，第二份在手术期间采集。与第二份血样一起，从每位患者身上获取少量牙龈和骨组织，以评估这些组织中的抗生素浓度（微生物学方法）。结果表明，巴卡西林在我们研究的血液和组织中均达到高浓度，且血液与牙龈及骨组织浓度之间存在直接对应关系。此外，应注意到我们的患者未发生术后感染。这些结果得出结论，巴卡西林似乎是治疗牙科感染的合适药物。
