Internal Medicine and Emergency Medicine, St'Andrea Hospital, Sapienza University, 00189 Rome, Italy.
Covid-Cardiology Unit, Madre Giuseppina Vannini Hospital, 00177 Rome, Italy.
Int J Environ Res Public Health. 2021 Jan 23;18(3):1003. doi: 10.3390/ijerph18031003.
Multidrug-resistant (MDR) organisms are emerging as some of the main healthcare problems worldwide. During the COVID-19 pandemic, several Infection Prevention and Control (IPC) measures have been adopted to reduce nosocomial microorganism transmission. We performed a case-control study to identify if the incidence of MDR bacterial infections while using pandemic-related preventive measures is lower than in previous years. From 2017 to 2020, we monitored hospital discharges over a four-month period (P #) (1 March to 30 June) in St. Andrea Hospital, Rome. In total, we reported 1617 discharges. Pearson's chi-squared test was used to identify significant differences. A value of ≤ 0.05 was considered statistically significant. A significant reduction in the incidence of total MDR bacterial infections was observed during the pandemic compared to in prepandemic years ( < 0.05). We also found a significantly higher incidence of MDR bacterial infections in COVID-19 departments compared with other medical departments (29% and 19%, respectively), with extended-spectrum -lactamase as the pathogens presenting the highest increase. This study demonstrates that maintaining a high level of preventive measures could help tackle an important health problem such as that of the spread of MDR bacteria.
多药耐药（MDR）生物体正在成为全球一些主要的医疗保健问题。在 COVID-19 大流行期间，已经采取了几项感染预防和控制（IPC）措施来减少医院内微生物的传播。我们进行了一项病例对照研究，以确定在使用与大流行相关的预防措施时，MDR 细菌感染的发生率是否低于前几年。我们在 2017 年至 2020 年期间监测了罗马圣安德烈亚医院四个月（P #）（3 月 1 日至 6 月 30 日）的出院情况。总共有 1617 名出院患者。我们使用皮尔逊卡方检验来确定显著差异。 ≤ 0.05 被认为具有统计学意义。与大流行前年份相比，大流行期间总 MDR 细菌感染的发生率显著降低（< 0.05）。我们还发现 COVID-19 病房的 MDR 细菌感染发生率明显高于其他医疗部门（分别为 29%和 19%），产extended-spectrum -lactamase 的病原体的增加率最高。这项研究表明，保持高水平的预防措施有助于解决 MDR 细菌传播等重要的健康问题。
