School of Life Science, Handong Global University, Pohang 37554, Korea.
Int J Mol Sci. 2021 Jan 24;22(3):1144. doi: 10.3390/ijms22031144.
Immunomodulation is on the cusp of being an important therapy for treating many diseases, due to the significant role of the immune system in defending the human body. Although the immune system is an essential defense system, overactivity can result in diverse sicknesses such as inflammation and autoimmune disease. Exosomes are emerging as a state-of-the-art therapeutic strategy for treating an overactive immune system. Thus, exosomes have drawn great interest for their potential clinical applications in treating diseases associated with abnormal immune regulation. Hence, in this review, we will discuss trends in exosome research related to inflammatory and autoimmune diseases. Possible therapeutic applications of exosomes will be summarized. Finally, an outlook to the future of exosomal therapy will be introduced.
免疫调节由于免疫系统在保护人体方面的重要作用，即将成为治疗许多疾病的重要疗法。尽管免疫系统是一种重要的防御系统，但过度活跃会导致各种疾病，如炎症和自身免疫性疾病。外泌体作为一种治疗过度活跃的免疫系统的最新治疗策略正在兴起。因此，外泌体因其在治疗与免疫调节异常相关的疾病方面的潜在临床应用而引起了极大的兴趣。因此，在这篇综述中，我们将讨论与炎症和自身免疫性疾病相关的外泌体研究趋势。将总结外泌体的可能治疗应用。最后，将介绍外泌体治疗的未来展望。
