Direito Rosa, Rocha João, Sepodes Bruno, Eduardo-Figueira Maria
Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal.
Department of Pharmacy, Pharmacology and Health Technologies, Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal.
Pharmaceutics. 2021 Jan 22;13(2):145. doi: 10.3390/pharmaceutics13020145.
Non-communicable chronic diseases (NCDs) are nowadays the principal cause of death, especially in most industrialized nations. These illnesses have increased exponentially with the consumption of diets very high in fat and sugar, not to mention stress and physical inactivity among other factors. The potential impact of suboptimal diets on NCDs' morbidity and mortality rates brings to the forefront the necessity for a new way of improving dietary habits. The literature provides extensive scientific work that presents evidence that phenolic compounds from diets have antioxidant, anti-inflammatory and antiproliferative activities that impact human health. Gut microbiota modulation by some phenolic compounds leads to favorable changes in abundance, diversity, and in the immune system. However, polyphenol's limited bioavailability needs to be overcome, highlighting their application in new delivery systems and providing their health benefits in well-established ways such as health maintenance, treatment or adjuvant to conventional pharmacological treatments. In this context, novel dietary approaches, including new food supplements, have emerged to prevent diseases and preserve health.
非传染性慢性病（NCDs）如今是主要的死亡原因，尤其是在大多数工业化国家。这些疾病随着高脂肪和高糖饮食的消费呈指数级增长，更不用说压力和缺乏身体活动等其他因素了。不良饮食对非传染性慢性病发病率和死亡率的潜在影响凸显了改善饮食习惯新方法的必要性。文献提供了大量科学研究，表明饮食中的酚类化合物具有抗氧化、抗炎和抗增殖活性，对人类健康有影响。一些酚类化合物对肠道微生物群的调节会导致其丰度、多样性以及免疫系统发生有利变化。然而，需要克服多酚生物利用度有限的问题，这突出了它们在新型递送系统中的应用，并以健康维护、治疗或作为传统药物治疗辅助手段等既定方式提供健康益处。在这种背景下，包括新型食品补充剂在内的新型饮食方法已经出现，以预防疾病和保持健康。
