Datta S, Kumar V M, Chhina G S, Singh B
Department of Physiology, All India Institute of Medical Sciences, New Delhi.
Exp Neurol. 1988 Apr;100(1):40-50. doi: 10.1016/0014-4886(88)90199-9.
The study investigated the possible interrelationship between changes in sleep-wakefulness and body temperature, primarily induced by manipulation of the noradrenergic system in the medial preoptic area. Saline, norepinephrine, and its alpha- and beta-blockers were injected in the medial preoptic area and in some control areas of rats, during their sleeping and active periods. 5-Hydroxytryptamine was injected in the medial preoptic area in another group of animals. Simultaneous changes in sleep-wakefulness and the body temperature were continuously recorded. Norepinephrine produced hypothermia and arousal, whereas alpha-adrenergic blockers induced hyperthermia and sleep. These changes in body temperature and in sleep-wakefulness did not follow an identical time course. 5-Hydroxytryptamine induced hyperthermia without affecting sleep-wakefulness. It is suggested that there are different neuronal mechanisms in the medial preoptic area that bring about the drug-induced changes in temperature and sleep-wakefulness.
该研究调查了睡眠-觉醒变化与体温变化之间可能存在的相互关系，这些变化主要是通过对内侧视前区去甲肾上腺素能系统的操作诱导产生的。在大鼠的睡眠期和活动期，将生理盐水、去甲肾上腺素及其α和β阻滞剂注射到内侧视前区和一些对照区域。在另一组动物的内侧视前区注射5-羟色胺。同时持续记录睡眠-觉醒和体温的变化。去甲肾上腺素导致体温过低和觉醒，而α-肾上腺素能阻滞剂则诱导体温过高和睡眠。体温和睡眠-觉醒的这些变化并不遵循相同的时间进程。5-羟色胺诱导体温过高但不影响睡眠-觉醒。提示内侧视前区存在不同的神经元机制，导致药物引起的体温和睡眠-觉醒变化。
