Mohan Kumar V, Datta S, Chhina G S, Singh B
Brain Res Bull. 1986 Apr;16(4):463-8. doi: 10.1016/0361-9230(86)90174-7.
The study is aimed at investigating the possible involvement of adrenergic mechanisms in the medial preoptic area (mPOA) for modulation of sleep-wakefulness in rats. In this study, saline, norepinephrine (NE), phenoxybenzamine (PBZ) and propranolol (PROP) were injected in the mPOA in different groups of male rats during the day and night. NE and PBZ were injected, during the day and the night respectively, in some control areas adjoining the mPOA in two other groups of animals. Arousal was produced by NE, and sleep by PBZ when they were applied in the mPOA. All other procedures, including application of NE and PBZ in the control areas and beta blocker (PROP) in the mPOA, did not produce alterations in sleep-wakefulness. These findings provide support for a physiological role played by the alpha adrenergic system in the mPOA for arousal, and area specificity of action of this system.
本研究旨在探讨肾上腺素能机制在大鼠内侧视前区（mPOA）对睡眠-觉醒调节中可能的参与情况。在本研究中，在白天和夜间分别向不同组的雄性大鼠的mPOA注射生理盐水、去甲肾上腺素（NE）、酚苄明（PBZ）和普萘洛尔（PROP）。在另外两组动物中，分别在白天和夜间向与mPOA相邻的一些对照区域注射NE和PBZ。当NE和PBZ应用于mPOA时，NE可引起觉醒，PBZ可诱导睡眠。所有其他操作，包括在对照区域应用NE和PBZ以及在mPOA应用β受体阻滞剂（PROP），均未引起睡眠-觉醒的改变。这些发现支持了α肾上腺素能系统在mPOA中对觉醒所起的生理作用，以及该系统作用的区域特异性。
