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关于创新化学实验室工作台的展望。

A Perspective on Innovating the Chemistry Lab Bench.

作者信息

Godfrey Alexander G, Michael Samuel G, Sittampalam Gurusingham Sitta, Zahoránszky-Köhalmi Gergely

机构信息

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, United States.

出版信息

Front Robot AI. 2020 Feb 25;7:24. doi: 10.3389/frobt.2020.00024. eCollection 2020.

Abstract

Innovating on the design and function of the chemical bench remains a quintessential challenge of the ages. It requires a deep understanding of the important role chemistry plays in scientific discovery as well a first principles approach to addressing the gaps in how work gets done at the bench. This perspective examines how one might explore designing and creating a sustainable new standard for advancing automated chemistry bench itself. We propose how this might be done by leveraging recent advances in laboratory automation whereby integrating the latest synthetic, analytical and information technologies, and AI/ML algorithms within a standardized framework, maximizes the value of the data generated and the broader utility of such systems. Although the context of this perspective focuses on the design of advancing molecule of potential therapeutic value, it would not be a stretch to contemplate how such systems could be applied to other applied disciplines like advanced materials, foodstuffs, or agricultural product development.

摘要

创新化学实验台的设计和功能仍然是一个长期存在的典型挑战。这需要深入理解化学在科学发现中所起的重要作用,以及采用第一性原理方法来解决实验台工作方式上的差距。本文探讨了如何探索设计和创建一个可持续的新标准,以推动自动化化学实验台本身的发展。我们提出,可以通过利用实验室自动化的最新进展来实现这一目标,即在标准化框架内整合最新的合成、分析和信息技术以及人工智能/机器学习算法,从而最大化所生成数据的价值以及此类系统的更广泛用途。尽管本文的背景侧重于设计具有潜在治疗价值的分子,但设想此类系统如何应用于其他应用学科,如先进材料、食品或农产品开发,也并非难事。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/094b/7805875/121b32be536a/frobt-07-00024-g0001.jpg

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