Kochhar T S
Division of Mathematics and Sciences, Kentucky State Univesity, Frankfort 40601.
Experientia. 1988 Jan 15;44(1):62-3. doi: 10.1007/BF01960247.
The influence of steroid hormones on the induction of sister-chromatid exchange (SCE) in cultured CHO cells was studied. It was observed that estradiol-17 beta, estriol, estrone and ethynyl estradiol treatments enhanced SCE rates compared to the controls. Overall, these compounds produced a dose response effect. The importance of a detailed study on the long-term genetic effects of steroids on mammalian cells is emphasized.
研究了甾体激素对培养的中国仓鼠卵巢(CHO)细胞中姐妹染色单体交换(SCE)诱导的影响。观察到,与对照组相比,17β-雌二醇、雌三醇、雌酮和乙炔雌二醇处理可提高SCE率。总体而言,这些化合物产生了剂量反应效应。强调了详细研究甾体激素对哺乳动物细胞长期遗传效应的重要性。