Kochhar T S
Toxicol Lett. 1985 Dec;29(2-3):201-6. doi: 10.1016/0378-4274(85)90042-6.
The effect of steroid hormones on the chromosomes of cultured Chinese hamster ovary (CHO) cells was studied. It was noticed that estradiol-17 beta, estrone, estriol and ethynyl estradiol were effective in producing various types of chromosome aberrations. The percentage of these abnormalities increased with increasing concentrations of steroids used. The importance of detailed and long-term investigations on the influence of these compounds on mammalian chromosomes is discussed.
研究了类固醇激素对培养的中国仓鼠卵巢（CHO）细胞染色体的影响。注意到17β-雌二醇、雌酮、雌三醇和乙炔雌二醇在产生各种类型的染色体畸变方面是有效的。这些异常的百分比随着所用类固醇浓度的增加而增加。讨论了对这些化合物对哺乳动物染色体影响进行详细和长期研究的重要性。
