Department of Biology, Emory University, Atlanta, GA 30322, USA.
Microb Genom. 2021 Feb;7(2). doi: 10.1099/mgen.0.000508.
Poly(A) polymerases (PAPs) and tRNA nucleotidyltransferases belong to a superfamily of nucleotidyltransferases and modify RNA 3'-ends. The product of the gene, PAP I, has been characterized in a few β-, γ- and δ-. Using the PAP I signature sequence, putative PAPs were identified in bacterial species from the α- and ε- and from four other bacterial phyla (, , and ). Phylogenetic analysis, alien index and G+C content calculations strongly suggest that the PAPs in the species identified in this study arose by horizontal gene transfer from the β- and γ-.
多聚(A)聚合酶(PAPs)和 tRNA 核苷酸转移酶属于核苷酸转移酶超家族,可修饰 RNA 3'末端。基因的产物 PAP I 已在少数β-、γ-和δ-中得到了表征。使用 PAP I 特征序列,在α-、ε-和另外四个细菌门(、、和)的细菌物种中鉴定出了假定的 PAP。系统发育分析、外源指数和 GC 含量计算强烈表明,本研究中鉴定的物种中的 PAP 是通过从β-和γ-的水平基因转移产生的。