Department of Biology, Emory University, Atlanta, GA, 30322, USA.
J Mol Evol. 2019 Sep;87(7-8):254-270. doi: 10.1007/s00239-019-09907-2. Epub 2019 Aug 21.
The tRNA nucleotidyltransferases and poly(A) polymerases belong to a superfamily of nucleotidyltransferases. The amino acid sequences of a number of bacterial tRNA nucleotidyltransferases and poly(A) polymerases have been used to construct a rooted, neighbor-joining phylogenetic tree. Using information gleaned from that analysis, along with data from the rRNA-based phylogenetic tree, structural data available on a number of members of the superfamily and other biochemical information on the superfamily, it is possible to suggest a scheme for the evolution of the bacterial tRNA nucleotidyltransferases and poly(A) polymerases from ancestral species. Elements of that scheme are discussed along with questions arising from the scheme which can be explored experimentally.
tRNA 核苷酸转移酶和多（A）聚合酶属于核苷酸转移酶的超家族。许多细菌 tRNA 核苷酸转移酶和多（A）聚合酶的氨基酸序列已被用于构建一个基于根的、邻接法系统发育树。利用该分析获得的信息，以及基于 rRNA 的系统发育树、该超家族一些成员的结构数据以及该超家族的其他生化信息，我们可以提出一个从原始物种进化而来的细菌 tRNA 核苷酸转移酶和多（A）聚合酶的方案。本文讨论了该方案的一些要素，以及可以通过实验探索的方案中出现的问题。
