Prevalence and risk analysis of mobile colistin resistance and extended-spectrum -lactamase genes carriage in pet dogs and their owners: a population based cross-sectional study.

Mobile colistin resistance gene and extended-spectrum -lactamase gene are highly prevalent in human - and pet-derived bacteria. Isolation of identical strains of -positive (MCRPEC) or -positive (CTX-MPEC) from pets and humans highlighted the potential for co-colonization of antibiotic-resistant bacteria which can be a risk for dissemination of resistance genes. In this study, the prevalence of and carriage from rectal swabs in 299 families (dogs and their owners) were 2.7 and 5.3%, respectively. We identified a significant association of carriage between dogs and their owners. Whilst antibiotic use in the previous three months was associated with carriage in dogs. Only one instance of dog and owner carrying identical CTX-MPEC was observed. Although the prevalence of identical strains in one family is rare, the huge number of dog ownership worldwide suggest that this threat should not be underestimated.