Liu Yang, Zhai Yimeng, Jiang Chenwei, Liu Huan, Li Zhenyu, Yuan Yafang, Song Jinfeng, Yuan Shuai
Zoetis Reference Laboratory, Shanghai, China.
JAC Antimicrob Resist. 2025 Jan 28;7(1):dlaf007. doi: 10.1093/jacamr/dlaf007. eCollection 2025 Feb.
In this study, bacteria isolated from companion animals in China were taxonomically identified and assessed for antimicrobial susceptibility to evaluate the prevalence of antimicrobial resistance (AMR) in pets.
From October 2022 to October 2023, 5468 samples were collected from pets, predominantly from cats and dogs, in China, of which 5253 bacterial strains were identified (>98%). Antimicrobial susceptibility was assessed using the VITEK 2 COMPACT system and the Kirby-Bauer disc diffusion method.
The most common bacterial species were (14.5%) and (13.6%). . exhibited high resistance to ampicillin and cefpodoxime (56.8%-73.2%) but moderate resistance to doxycycline, trimethoprim-sulfamethoxazole, enrofloxacin, gentamicin, and amoxicillin-clavulanate (18.1%-38.5%). spp. and spp. were resistance to several antimicrobials (32.2%-57.7%). High susceptibility to imipenem was noted in spp., spp., and spp. (91.7%-94.1%). Coagulase-positive spp. demonstrated higher resistance than coagulase-negative strains. showed greater resistance to some antimicrobials compared with . spp. exhibited low resistance to enrofloxacin (1.6%) and penicillin (1.1%).
The study demonstrates that AMR is widespread in companion animals in China, emphasizing the need for continuous surveillance. The accumulation of commercial antimicrobial susceptibility data can improve understanding of AMR and promote more effective antimicrobial stewardship and clinical practices in veterinary medicine.
在本研究中，对从中国伴侣动物中分离出的细菌进行分类鉴定，并评估其对抗菌药物的敏感性，以评估宠物中抗菌药物耐药性（AMR）的流行情况。
2022年10月至2023年10月，从中国的宠物（主要是猫和狗）中收集了5468份样本，其中鉴定出5253株细菌（>98%）。使用VITEK 2 COMPACT系统和 Kirby-Bauer纸片扩散法评估抗菌药物敏感性。
最常见的细菌种类是[具体细菌种类1]（14.5%）和[具体细菌种类2]（13.6%）。[具体细菌种类1]对氨苄西林和头孢泊肟表现出高耐药性（56.8%-73.2%），但对多西环素、甲氧苄啶-磺胺甲恶唑、恩诺沙星、庆大霉素和阿莫西林-克拉维酸表现出中度耐药性（18.1%-38.5%）。[具体细菌种类3]属和[具体细菌种类4]属对几种抗菌药物耐药（32.2%-57.7%）。[具体细菌种类5]属、[具体细菌种类6]属和[具体细菌种类7]属对亚胺培南高度敏感（91.7%-94.1%）。凝固酶阳性葡萄球菌属表现出比凝固酶阴性菌株更高的耐药性。[具体细菌种类8]与[具体细菌种类9]相比，对某些抗菌药物表现出更高的耐药性。[具体细菌种类10]属对恩诺沙星（1.6%）和青霉素（1.1%）表现出低耐药性。
该研究表明，AMR在中国伴侣动物中广泛存在，强调了持续监测的必要性。商业抗菌药物敏感性数据的积累可以增进对AMR的了解，并促进兽医医学中更有效的抗菌药物管理和临床实践。
