School of Mathematical Sciences, Qufu Normal University, Qufu 273165, People's Republic of China.
School of Mathematical Sciences, Zhejiang University, Hangzhou 310027, People's Republic of China.
Phys Med Biol. 2021 Feb 25;66(5):055022. doi: 10.1088/1361-6560/abe052.
Fast calculation or simulation of the ablation zone induced by radiofrequency ablation (RFA) has a critical role in hepatic RFA planning and therapy. However, it remains challenging to approximate the ablation zone in real time, especially when more than one probe is involved in one ablation session. This paper presents a novel computational technique to calculate the 3D ablation zone of one probe RFA and two-probe switching RFA. The main idea is to get an approximate solution of the temperature distribution from a simplified Pennes bioheat equation, and further fit the solution to the coagulation measurements on ex vivo porcine liver. With a closed-form solution of temperature distribution, the calculation of the ablation zone is as simple as the commonly used ellipsoidal model, but it allows a more realistic prediction of combined ablation zones with different inter-probe spacing. The new approximation technique could potentially replace the original ellipsoidal model in the intervention planning step.
快速计算或模拟射频消融（RFA）引起的消融区在肝 RFA 规划和治疗中具有关键作用。然而，实时逼近消融区仍然具有挑战性，特别是当一个消融疗程中涉及多个探头时。本文提出了一种新的计算技术，用于计算单探头 RFA 和双探头切换 RFA 的 3D 消融区。其主要思想是从简化的 Pennes 生物传热方程中获得温度分布的近似解，并进一步将该解拟合到离体猪肝上的凝固测量值。由于具有温度分布的闭式解，消融区的计算与常用的椭球模型一样简单，但它可以更真实地预测不同探头间距的组合消融区。新的近似技术有可能在介入规划步骤中替代原始的椭球模型。
