Han K, Wang S S, Jia W P, Yang S S, Cao W Z, Zhao Y L, Zhu Q, Ning C X, Liu M, He Y
Institute of Geriatrics, Beijing Key Laboratory of Research on Aging and Related Diseases, State Key Laboratory of Kidney Disease, National Clinical Research Center for Geriatrics Diseases, Chinese People's Liberation Army General Hospital,Beijing 100853, China.
Central Laboratory of Hainan Hospital, Chinese People's Liberation Army General Hospital, Sanya 572013, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2021 Jan 10;42(1):88-93. doi: 10.3760/cma.j.cn112338-20200424-00637.
To investigate the association between serum albumin levels and health-related quality of life in centenarians in Hainan province, China. We conducted a full sample centenarian cohort study in a community population in Hainan from 2014 to 2016, which included 1 002 centenarians for questionnaire surveys, physical examinations and biological tests. The EQ-5D-VAS scale was used to evaluate health-related quality of life, and multiple linear regression and multiple logistic regression analyses were used to analyze the association between serum albumin levels and health-related quality of life. There was a positive linear relationship between serum albumin levels and EQ-5D/VAS score. The normalized values in the fully adjusted model was 0.156 (<0.001). In the multivariate logistic regression analysis, after fully adjusting the covariates, the risk of health related life quality impairment in the lower albumin group was 2.369 times(95%: 1.424-3.939) than that in the higher albumin group. Gender stratified analyses showed that the was 4.406 (95%: 1.537-12.631) in male centenarians and 2.035 (95%: 1.125-3.680) in female centenarians. Lower serum albumin level was associated with impaired health-related quality of life in centenarians in Hainan.
为研究中国海南省百岁老人血清白蛋白水平与健康相关生活质量之间的关联。我们于2014年至2016年在海南省的一个社区人群中开展了一项全样本百岁老人队列研究，该研究纳入了1002名百岁老人进行问卷调查、体格检查和生物学检测。采用EQ-5D-VAS量表评估健康相关生活质量，并运用多重线性回归和多重逻辑回归分析血清白蛋白水平与健康相关生活质量之间的关联。血清白蛋白水平与EQ-5D/VAS评分之间存在正线性关系。完全调整模型中的标准化值为0.156（<0.001）。在多因素逻辑回归分析中，在对协变量进行完全调整后，低白蛋白组健康相关生活质量受损的风险是高白蛋白组的2.369倍（95%：1.424 - 3.939）。性别分层分析显示，男性百岁老人中的该值为4.406（95%：1.537 - 12.631），女性百岁老人中的该值为2.035（95%：1.125 - 3.680）。较低的血清白蛋白水平与海南省百岁老人健康相关生活质量受损有关。
