Section of Clinical Nutrition and Nutrigenomic, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
School of Specialization in Food Science, University of Rome Tor Vergata, 00133 Rome, Italy.
Nutrients. 2021 Jan 25;13(2):358. doi: 10.3390/nu13020358.
Lipoedema is a subcutaneous adipose tissue disease characterized by the increase in the amount and structure of fat mass (FM) in specific areas, causing pain and discomfort. 95% of patients fail to lose weight in the lipoedema areas. The study was conducted to evaluate body composition and general health status modification in a group of lipoedema patients (LIPPY) and a control group (CTRL) after four weeks of a modified Mediterranean diet therapy (mMeD). A total of 29 subjects were included in the data analysis, divided in two groups: 14 LIPPY and 15 CTRL. After the mMeD, both groups significantly decreased their weight and body mass index; the CTRL also showed a reduction of all the circumferences and all FM's compartments. LIPPY showed a decrease of FM in upper and lower limbs. No significant differences in Δ% between the groups were observed for the lean mass (LM). In LIPPY, an increase in the patients' ability to perform various daily physical activities related to the loss of arms' and legs' fat was observed. According to the European Quality of Life scale, the possibility for LIPPY subjects to perform simple daily activities with less fatigue, pain and anxiety is highlighted. Further long-term studies are recommended to confirm the mMeD as a good strategy for Lipoedema treatment.
脂肪营养不良是一种皮下脂肪组织疾病，其特征是特定区域内脂肪量和结构的增加，导致疼痛和不适。95%的患者在脂肪营养不良区域无法减肥。本研究旨在评估经过四周改良地中海饮食疗法（mMeD）后，一组脂肪营养不良患者（LIPPY）和对照组（CTRL）的身体成分和整体健康状况的改变。共有 29 名受试者纳入数据分析，分为两组：14 名 LIPPY 和 15 名 CTRL。经过 mMeD，两组的体重和体重指数均显著下降；CTRL 还显示所有周长和所有 FM 隔室的减少。LIPPY 上肢和下肢的 FM 减少。两组之间的去脂体重（LM）的 Δ% 没有显著差异。在 LIPPY 中，观察到患者进行与手臂和腿部脂肪减少相关的各种日常体力活动的能力提高。根据欧洲生活质量量表，LIPPY 患者进行简单日常活动的可能性更大，疲劳、疼痛和焦虑感更少。建议进行进一步的长期研究，以证实 mMeD 是治疗脂肪营养不良的一种良好策略。
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