Jeziorek Małgorzata, Wuczyński Maciej, Sowicz Monika, Adaszyńska Agnieszka, Szuba Andrzej, Chachaj Angelika
Department of Dietetics and Bromatology, Faculty of Pharmacy, Wroclaw Medical University, 50-367 Wroclaw, Poland.
Statistical Analysis Centre, Wroclaw Medical University, 50-372 Wroclaw, Poland.
Biomedicines. 2025 Apr 3;13(4):867. doi: 10.3390/biomedicines13040867.
Lipedema is a chronic disorder characterized by disproportionate fat accumulation in the extremities, predominantly affecting women. Unlike obesity, lipedema might be associated with a lower prevalence of metabolic alterations despite often coexisting with overweight or obesity. Fat distribution plays a crucial role in metabolic differences, with gynoid fat in lipedema being associated with a lower risk of insulin resistance and cardiovascular disease. The present study aims to compare biochemical parameters between women with lipedema and those with lifestyle-induced overweight/obesity. : This study involved 108 women, including 53 with lipedema and 55 with lifestyle-induced overweight/obesity. Anthropometric measurements and body composition analyses were conducted, and biochemical parameters related to liver function, lipid profile, kidney and thyroid function, uric acid levels, and carbohydrate metabolism were assessed. Statistical comparisons were made between groups, and multivariate models were used to explore the relationships between disease type, metabolic parameters, and body composition. : Women with lipedema exhibited a more favorable metabolic profile than those with overweight/obesity. Dyslipidemia was observed in ~50% of the lipedema group, compared to nearly 70% in the overweight/obesity group. Impaired glucose metabolism and insulin resistance were significantly less prevalent in the lipedema group (18.9% vs. 43.6%, < 0.05). : Despite having a high BMI, women with lipedema demonstrate fewer metabolic alterations than those with overweight/obesity. Fat distribution, rather than overall adiposity, appears to influence metabolic risk. These findings highlight the need for targeted therapeutic approaches to lipedema, distinct from conventional obesity management strategies.
脂肪性水肿是一种慢性疾病，其特征是四肢脂肪过度堆积，主要影响女性。与肥胖不同，脂肪性水肿可能与代谢改变的患病率较低有关，尽管它常与超重或肥胖并存。脂肪分布在代谢差异中起着关键作用，脂肪性水肿中的臀部脂肪与胰岛素抵抗和心血管疾病的较低风险相关。本研究旨在比较脂肪性水肿女性与生活方式导致的超重/肥胖女性之间的生化参数。：本研究纳入了108名女性，其中53名患有脂肪性水肿，55名患有生活方式导致的超重/肥胖。进行了人体测量和身体成分分析，并评估了与肝功能、血脂谱、肾脏和甲状腺功能、尿酸水平以及碳水化合物代谢相关的生化参数。对两组进行了统计学比较，并使用多变量模型探讨疾病类型、代谢参数和身体成分之间的关系。：与超重/肥胖女性相比，脂肪性水肿女性的代谢状况更有利。脂肪性水肿组约50%的人出现血脂异常，而超重/肥胖组这一比例接近70%。脂肪性水肿组葡萄糖代谢受损和胰岛素抵抗的患病率显著较低（18.9%对43.6%，<0.05）。：尽管脂肪性水肿女性的体重指数较高，但与超重/肥胖女性相比，她们的代谢改变较少。似乎是脂肪分布而非总体肥胖程度影响代谢风险。这些发现凸显了针对脂肪性水肿采取有针对性治疗方法的必要性，这与传统的肥胖管理策略不同。
