胃蛋白酶的分泌
The secretion of pepsin.
作者信息
Kondo T, Magee D F
出版信息
J Physiol. 1977 Aug;270(1):29-36. doi: 10.1113/jphysiol.1977.sp011936.
Abstract
- Ligation and division of the vessels supplying the stomach, except those from the spleen, result in greatly increased pepsin secretion in response to pentagastrin, pilocarpine or 2-deoxy-D-glucose. 2. This effect was still present 6 months after initial ligation. 3. Analysis of dose-response curves shows that for pepsin secretion the Vmax values were raised by this procedure. 4. Right-sided vessel ligation and division does not alter acid secretion in response to the stimuli used. 5. It is suspected that the procedure of right-sided vessel ligation removes a non-competitive inhibitor mechanism to gastric pepsin secretion.
摘要
- 结扎并切断供应胃的血管（脾动脉分支除外）后，胃泌素、毛果芸香碱或2-脱氧-D-葡萄糖刺激引起的胃蛋白酶分泌显著增加。2. 初次结扎6个月后，这种效应仍然存在。3. 剂量反应曲线分析表明，该操作提高了胃蛋白酶分泌的Vmax值。4. 右侧血管结扎和切断不改变所用刺激引起的胃酸分泌。5. 怀疑右侧血管结扎操作消除了胃蛋白酶分泌的非竞争性抑制机制。
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