使用黏膜冷却实验得出的胃窦对五肽胃泌素抑制作用的证据。
Evidence for antral inhibition of pentagastrin from experiments using mucosal cooling.
作者信息
Kondo T, Magee D F
出版信息
J Physiol. 1977 Aug;270(1):37-50. doi: 10.1113/jphysiol.1977.sp011937.
Abstract
- The acid secretion of the fundic mucosa in Heidenhain pouches in response to pentagastrin became progressively less as the pouch mucosa was cooled. 2. When a cooled Heidenhain pouch in an animal receiving pentagastrin was warmed, acid and pepsin secretion from the main stomach was depressed. Change from warm to cool produced no obvious effect. 3. In animals receiving pentagastrin continuously, but not in those receiving histamine, lowering the temperature in an antral pouch, or the application of local anaesthetics to its mucosa, increased acid and pepsin secretion from the main stomach when the antral pouch was fully innervated. 4. This effect could readily be abolished by ganglionic and beta-adrenergic blockade, but not by bilateral vagal block in the neck, thus suggesting a sympathetically mediated inhibitory mechanism of pyloric origin. 5. The effect of indirect vagal stimulation, using 2-deoxy-D-glucose on secretion from the main stomach, was augmented by pyloric antral local anaesthesia and depressed by antral cooling.
摘要
- 随着海登海因小胃黏膜冷却，其对五肽胃泌素的胃酸分泌逐渐减少。2. 当给接受五肽胃泌素的动物的冷却海登海因小胃加温时，主胃的胃酸和胃蛋白酶分泌受到抑制。从温变凉则无明显影响。3. 在持续接受五肽胃泌素的动物中，但在接受组胺的动物中未出现这种情况，当胃窦小胃完全有神经支配时，降低胃窦小胃的温度或对其黏膜应用局部麻醉剂，会增加主胃的胃酸和胃蛋白酶分泌。4. 这种效应可通过神经节阻断和β-肾上腺素能阻断轻易消除，但不能通过颈部双侧迷走神经阻断消除，因此提示存在一种由交感神经介导的幽门起源的抑制机制。5. 使用2-脱氧-D-葡萄糖进行间接迷走神经刺激对主胃分泌的影响，会因幽门窦局部麻醉而增强，因窦部冷却而受到抑制。
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