了解宿主对葡萄球菌性烫伤样皮肤综合征的反应。
Understanding host's response to staphylococcal scalded skin syndrome.
作者信息
Rouva Glykeria, Vergadi Eleni, Krasagakis Konstantinos, Galanakis Emmanouil
机构信息
Department of Paediatrics, School of Medicine, University of Crete, Heraklion, Greece.
Dermatology, School of Medicine, University of Crete, Heraklion, Greece.
出版信息
Acta Paediatr. 2025 Feb;114(2):241-247. doi: 10.1111/apa.17462. Epub 2024 Oct 16.
AIM
The aim of this review was to summarise the current knowledge on host-related factors that contribute to the development and severity of staphylococcal scalded skin syndrome (SSSS) in children.
METHODS
A comprehensive assessment and analysis of the existing literature on SSSS clinical features, pathogenesis and susceptibility factors.
RESULTS
SSSS is a blistering skin disease caused by circulating exfoliative toxins (ETs) of Staphylococcus aureus (S. aureus), almost exclusively affecting infants, young children and immunocompromised individuals. ETs possess serine protease activity and target desmoglein-1 (Dsg-1) in the superficial epidermis. While the role of S. aureus ETs and site of action are well-described, other host factors such as impaired immune responses to ETs, poor renal clearance and genetic factors are crucial for the onset of and/or the severity of SSSS in children.
CONCLUSION
The fate of desmosomal fractions after cleavage by ETs, as well as the role of dermal inflammatory cell infiltrates remain to be elucidated.
目的
本综述旨在总结目前关于宿主相关因素的知识，这些因素导致儿童葡萄球菌性烫伤样皮肤综合征（SSSS）的发生和严重程度。
方法
对现有关于SSSS临床特征、发病机制和易感因素的文献进行全面评估和分析。
结果
SSSS是一种由金黄色葡萄球菌（S. aureus）循环剥脱毒素（ETs）引起的水疱性皮肤病，几乎只影响婴儿、幼儿和免疫功能低下的个体。ETs具有丝氨酸蛋白酶活性，作用于表皮浅层的桥粒芯糖蛋白-1（Dsg-1）。虽然金黄色葡萄球菌ETs的作用和作用部位已得到充分描述，但其他宿主因素，如对ETs的免疫反应受损、肾脏清除功能差和遗传因素，对儿童SSSS的发病和/或严重程度至关重要。
结论
ETs切割后桥粒成分的命运以及真皮炎性细胞浸润的作用仍有待阐明。
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