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[药物名称]对偏头痛的疗效：临床应用及实验证据的启示

The Effectiveness of on Migraine: Implications from Clinical Use and Experimental Proof.

作者信息

Liao Chung-Chih, Liao Ke-Ru, Lin Cheng-Li, Li Jung-Miao

机构信息

Graduate Institute of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.

Department of Neurology, Yuanlin Christian Hospital, Yuanlin 51052, Taiwan.

出版信息

Evid Based Complement Alternat Med. 2021 Jan 6;2021:8707280. doi: 10.1155/2021/8707280. eCollection 2021.

DOI:10.1155/2021/8707280
PMID:33505504
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7806391/
Abstract

BACKGROUND

(SB), a traditional Chinese medicine, is commonly used for the treatment of inflammatory and painful conditions. The purpose of the present study was to examine the effects of SB on migraine.

MATERIALS AND METHODS

We examined the clinical applications of SB based on the data obtained from Taiwan's National Health Insurance Research Database and confirmed that it was frequently used in Taiwan for the treatment of headaches. An experimental migraine model was established in rats by an intraperitoneal injection of nitroglycerin (NTG, 10 mg/kg). Pretreatment with SB was given orally 30 min before NTG administration. The rats were subjected to migraine-related behaviour tests that were video-recorded and analysed using EthoVision XT 12.0 software.

RESULTS

The frequency of exploratory and locomotor behaviour was comparatively lower in the NTG group than that in the control group, while the frequency of resting and grooming behaviour increased. These phenomena were ameliorated by pretreatment with 1.0 g/kg SB. The total time spent on the smooth surface was longer in the NTG group than that in the control group, but the time was shortened by pretreatment with 1.0 g/kg SB.

CONCLUSIONS

Pretreatment with 1.0 g/kg SB relieved migraine-related behaviours in the experimental NTG-induced migraine model. The outcome therefore demonstrated that pretreatment with 1.0 g/kg SB is beneficial for migraine treatment.

摘要

背景

四物汤是一种传统中药，常用于治疗炎症和疼痛病症。本研究的目的是考察四物汤对偏头痛的影响。

材料与方法

我们基于从台湾国民健康保险研究数据库获得的数据，考察了四物汤的临床应用情况，并确认其在台湾常用于治疗头痛。通过腹腔注射硝酸甘油（NTG，10毫克/千克）在大鼠中建立实验性偏头痛模型。在给予NTG前30分钟口服四物汤进行预处理。对大鼠进行与偏头痛相关的行为测试，并使用EthoVision XT 12.0软件对测试进行视频记录和分析。

结果

NTG组的探究和运动行为频率相较于对照组较低，而静息和梳理行为的频率增加。用1.0克/千克四物汤预处理可改善这些现象。NTG组在光滑表面上花费的总时间比对照组更长，但用1.0克/千克四物汤预处理可缩短该时间。

结论

用1.0克/千克四物汤预处理可缓解实验性NTG诱导的偏头痛模型中与偏头痛相关的行为。因此，该结果表明用1.0克/千克四物汤预处理对偏头痛治疗有益。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c7c/7806391/59dbebc2a579/ECAM2021-8707280.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c7c/7806391/992742456fd1/ECAM2021-8707280.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c7c/7806391/675b744cff36/ECAM2021-8707280.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c7c/7806391/68b4ed1dd8a4/ECAM2021-8707280.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c7c/7806391/5be9f2422033/ECAM2021-8707280.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c7c/7806391/59dbebc2a579/ECAM2021-8707280.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c7c/7806391/992742456fd1/ECAM2021-8707280.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c7c/7806391/675b744cff36/ECAM2021-8707280.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c7c/7806391/68b4ed1dd8a4/ECAM2021-8707280.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c7c/7806391/5be9f2422033/ECAM2021-8707280.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c7c/7806391/59dbebc2a579/ECAM2021-8707280.005.jpg

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