Shen Guangyu, Wu Jing, Ye Bang-Ce, Qi Nan
Institute of Engineering Biology and Health, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, China.
Can J Infect Dis Med Microbiol. 2021 Jan 8;2021:6658674. doi: 10.1155/2021/6658674. eCollection 2021.
Gut microbiota is increasingly recognized as a metabolic organ essential for human health. Compelling evidences show a variety set of links between diets and gut microbial homeostasis. Changes in gut microbial flora would probably contribute to the development of certain diseases such as diabetes, heart disease, allergy, and psychiatric diseases. In addition to the composition of gut microbiota, the metabolites derived from gut microbiota have emerged as a pivotal regulator in diseases development. Since high-fat and high-protein diets substantially affect the gut microbial ecology and human health, the current review summarizes the gut microbiota-derived metabolites such as short-chain fatty acids (SCFAs), amino acids, and their derivatives and highlights the mechanisms underlying the host responses to these bioactive substances.
肠道微生物群越来越被认为是对人类健康至关重要的代谢器官。有力证据表明饮食与肠道微生物稳态之间存在多种联系。肠道微生物群的变化可能会导致某些疾病的发生，如糖尿病、心脏病、过敏和精神疾病。除了肠道微生物群的组成外，源自肠道微生物群的代谢产物已成为疾病发展的关键调节因子。由于高脂肪和高蛋白饮食会显著影响肠道微生物生态和人类健康，本综述总结了肠道微生物群衍生的代谢产物，如短链脂肪酸（SCFAs）、氨基酸及其衍生物，并强调了宿主对这些生物活性物质反应的潜在机制。
