Sow Maïmouna, Diagne Nafissatou, Djiba Boundia, Kane Baïdy Sy, Dieng Mouhamed, Ndao Awa Cheikh, Faye Atoumane, Pouye Abdoulaye
Département de Médecine Interne, Hôpital universitaire de Dantec, Dakar, Sénégal.
Pan Afr Med J. 2020 Nov 2;37:207. doi: 10.11604/pamj.2020.37.207.24900. eCollection 2020.
Thyrotoxic hypokalemic periodic paralysis is a rare complication of hyperthyroidism. It has been most often reported in Asian subjects while it has been little described in the black population. Its mechanism has been little elucidated, but it would be caused by hyperactivity of the Na+/K+pump. We here report two cases of thyrotoxic hypokalemic periodic paralysis in black African subjects. The clinical manifestation was identical in both patients: proximal muscle paralysis of the lower limbs. Paralysis was associated with severe hypokalemia and occurred in female patients treated for Graves' disease without any other associated disease. Outcome was immediately favorable under potassium supplementation. Treatment of hyperthyroidism prevented recurrences. This study highlights the importance of suspecting the diagnosis of thyrotoxic hypokalemic periodic paralysis despite its rarity in the black African population.
甲状腺毒症性低钾性周期性麻痹是甲状腺功能亢进症的一种罕见并发症。它在亚洲人群中报道最为常见，而在黑人人群中描述较少。其发病机制尚未完全阐明，但可能由钠钾泵活性亢进引起。我们在此报告两例非洲黑人甲状腺毒症性低钾性周期性麻痹病例。两名患者的临床表现相同：下肢近端肌肉麻痹。麻痹与严重低钾血症相关，发生在患有格雷夫斯病且无其他相关疾病的女性患者中。补充钾后病情立即好转。治疗甲状腺功能亢进症可预防复发。本研究强调了尽管甲状腺毒症性低钾性周期性麻痹在非洲黑人人群中罕见，但仍需怀疑其诊断的重要性。
