用于保护赫里福德牛免受微小牛蜱侵害的疫苗。
Vaccines to protect Hereford cattle against the cattle tick, Boophilus microplus.
作者信息
Opdebeeck J P, Wong J Y, Jackson L A, Dobson C
机构信息
Department of Parasitology, University of Queensland, St Lucia, Australia.
出版信息
Immunology. 1988 Mar;63(3):363-7.
Abstract
Vaccines made from gut and gut and synganglion tissue dissected from Boophilus microplus gave 87% and 80% protection, respectively, compared with adjuvant-injected controls in cattle against three infestations with 20,000 larval ticks administered over 14 days. A vaccine prepared from synganglion alone did not protect cattle. Ticks collected from vaccinated cattle produced 95% and 91% fewer eggs, respectively, than ticks from control animals. Vaccinated cattle were protected (36%) 7 months after they had been immunized with tick antigens. Antibody responses to the vaccines were detected by enzyme-linked immunosorbent assay (ELISA).
摘要
用微小牛蜱肠道和神经节组织制成的疫苗，与佐剂注射对照组相比，在牛身上分别提供了87%和80%的保护率，可抵御在14天内分三次接种20000只幼虫蜱的侵袭。仅用神经节制备的疫苗不能保护牛。从接种疫苗的牛身上采集的蜱产卵量分别比对照动物的蜱少95%和91%。接种疫苗的牛在接种蜱抗原7个月后仍受到保护（36%）。通过酶联免疫吸附测定（ELISA）检测对疫苗的抗体反应。
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