儿童胃黏膜巨肥厚症的诊断与管理：病例系列回顾
Diagnosis and Management of Ménétrier Disease in Children: A Case Series Review.
作者信息
Krikilion Jasmina, Levy Elvira Ingrid, Vandenplas Yvan
机构信息
KidZ Health Castle, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.
出版信息
Pediatr Gastroenterol Hepatol Nutr. 2021 Jan;24(1):109-117. doi: 10.5223/pghn.2021.24.1.109. Epub 2021 Jan 8.
PURPOSE
Ménétrier disease (MD) was first described in 1888, and 50 cases have been reported until now. We aimed to discuss the etiology, diagnostics, and management of MD in children.
METHODS
We searched for case reports published from 2014 till 2019 in English using PubMed. Articles were selected using subject headings and key words of interest to the topic. Interesting references of the included articles were also included.
RESULTS
The pathophysiology of MD is still uncertain. However, overexpression of transforming growth factor alpha with transformation of the gastric mucosa has been observed, which may be mediated by genetics and provoked by an infectious trigger. Clinically, MD is diagnosed by abdominal pain, vomiting, anorexia, and edema secondary to hypoalbuminemia. A gastroscopy with biopsy is the gold standard for the diagnosis of MD. In children, the disease is self-limiting and only requires supportive treatment. In general, children have a good prognosis and recover spontaneously within a few weeks.
CONCLUSION
Few pediatric cases of MD have been described in recent years, and with all different etiology. Endoscopy with biopsy remains the golden standard for the diagnosis of MD, and in children, the disease is self-limiting.
目的
胃黏膜巨肥厚症（MD）于1888年首次被描述，至今已报告50例。我们旨在探讨儿童MD的病因、诊断和治疗。
方法
我们使用PubMed搜索了2014年至2019年以英文发表的病例报告。通过主题词和与该主题相关的关键词来选择文章。纳入文章的相关参考文献也被纳入。
结果
MD的病理生理学仍不确定。然而，已观察到转化生长因子α过表达伴胃黏膜转化，这可能由遗传介导并由感染触发因素诱发。临床上，MD通过腹痛、呕吐、厌食以及低蛋白血症继发的水肿来诊断。胃镜检查及活检是MD诊断的金标准。在儿童中，该病具有自限性，仅需支持治疗。一般来说，儿童预后良好，几周内可自发恢复。
结论
近年来儿童MD病例报道较少，且病因各异。内镜检查及活检仍是MD诊断的金标准，在儿童中，该病具有自限性。
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