Keener Myles, Waack Andrew, Ranabothu Meghana, Ranabothu Akash, Vattipally Venkatramana R
College of Medicine and Life Sciences, The University of Toledo College of Medicine and Life Sciences, Toledo, USA.
Neurological Surgery, The University of Toledo College of Medicine and Life Sciences, Toledo, USA.
Cureus. 2023 Sep 19;15(9):e45537. doi: 10.7759/cureus.45537. eCollection 2023 Sep.
We present a case report describing the diagnosis and management of a patient who presents with a rare diagnosis of Menetrier's disease. This condition poses a diagnostic challenge to clinicians due to its nonspecific clinical presentation and is oftentimes misdiagnosed for more common gastric disorders. Menetrier's disease is characterized by gastric mucosal hypertrophy and subsequent protein loss, resulting in gastric symptoms and widespread edema. While the etiology remains unclear, notable associations have been observed with () infection and overexpression of transforming growth factor-alpha (TGF-a). The management often involves supportive measures with medical and surgical interventions for refractory cases and when necessary. This report includes a comprehensive review of the literature on the clinical presentation, diagnostic approach, and management of this rare disease. By documenting such cases in the medical literature, we aim to enhance the clinician's ability to recognize and manage this disorder, thereby preventing the development of more severe manifestations such as gastric carcinoma.
我们报告一例病例,描述了一名被诊断为罕见的梅内特里耶病患者的诊断和治疗情况。由于其临床表现不具特异性,这种疾病给临床医生带来了诊断挑战,并且常常被误诊为更常见的胃部疾病。梅内特里耶病的特征是胃黏膜肥大以及随后的蛋白质丢失,导致胃部症状和广泛水肿。虽然病因尚不清楚,但已观察到与()感染和转化生长因子-α(TGF-α)的过表达有显著关联。治疗通常包括支持性措施,对于难治性病例以及必要时采用药物和手术干预。本报告全面回顾了关于这种罕见疾病的临床表现、诊断方法和治疗的文献。通过在医学文献中记录此类病例,我们旨在提高临床医生识别和管理这种疾病的能力,从而预防诸如胃癌等更严重表现的发生。