University of Groningen, University Medical Center Groningen, Biomedical Engineering Department-FB40, Groningen, The Netherlands.
University of Groningen, University Medical Center Groningen, W.J. Kolff Institute for Biomedical Engineering and Materials Science, Groningen, The Netherlands.
J Pathol. 2021 Jul;254(4):344-357. doi: 10.1002/path.5632. Epub 2021 Mar 3.
Fibrosis results from aberrant wound healing and is characterized by an accumulation of extracellular matrix, impairing the function of an affected organ. Increased deposition of extracellular matrix proteins, disruption of matrix degradation, but also abnormal post-translational modifications alter the biochemical composition and biophysical properties of the tissue microenvironment - the stroma. Macrophages are known to play an important role in wound healing and tissue repair, but the direct influence of fibrotic stroma on macrophage behaviour is still an under-investigated element in the pathogenesis of fibrosis. In this review, the current knowledge on interactions between macrophages and (fibrotic) stroma will be discussed from biochemical, biophysical, and cellular perspectives. Furthermore, we provide future perspectives with regard to how macrophage-stroma interactions can be examined further to ultimately facilitate more specific targeting of these interactions in the treatment of fibrosis. © 2021 The Authors. The Journal of Pathology published by John Wiley & Sons, Ltd. on behalf of The Pathological Society of Great Britain and Ireland.
纤维化是由异常的伤口愈合引起的，其特征是细胞外基质的积累，从而损害受影响器官的功能。细胞外基质蛋白的沉积增加、基质降解的破坏，以及异常的翻译后修饰，改变了组织微环境（基质）的生化组成和生物物理特性。众所周知，巨噬细胞在伤口愈合和组织修复中起着重要作用，但纤维化基质对巨噬细胞行为的直接影响仍然是纤维化发病机制中研究不足的一个因素。在这篇综述中，我们将从生化、生物物理和细胞的角度讨论巨噬细胞和（纤维化）基质之间的相互作用的现有知识。此外，我们还提供了关于如何进一步研究巨噬细胞-基质相互作用的未来展望，以期最终更有针对性地治疗纤维化。 © 2021 作者。The Journal of Pathology 由 John Wiley & Sons, Ltd. 代表英国和爱尔兰的病理学学会出版。
