Mutsaers S E, Bishop J E, McGrouther G, Laurent G J
Centre for Cardiopulmonary Biochemistry and Respiratory Medicine, University College London Medical School, Rayne Institute, U.K.
Int J Biochem Cell Biol. 1997 Jan;29(1):5-17. doi: 10.1016/s1357-2725(96)00115-x.
To set the scene for this Directed Issue on Mechanisms of Tissue Repair of The International Journal of Biochemistry and Cell Biology, this introductory overview briefly describes the process of wound healing and highlights some of the key recent advances in this field of research. It emphasizes the importance of cell-cell and cell-matrix interactions, particularly relating to the role of cell surface adhesion molecules, and describes developments that have led to a better understanding of the dynamic nature of matrix turnover with reference to negative and positive mediators that regulate procollagen gene expression and protein production. An important component of this Directed Issue is concerned with the development of tissue fibrosis, which accompanies a number of disease states and demonstrates remarkable parallels with the normal wound healing process; excessive amounts of matrix are laid down but the resolution of scarring, which would be anticipated in wound healing, is impaired. The possible mechanisms involved in fibrosis are discussed here. Since cytokines play an important role in regulating cell function such as proliferation, migration and matrix synthesis, it is the balance of these mediators which is likely to play a key role in regulating the initiation, progression and resolution of wounds. Finally, this review highlights areas of tissue repair research in which recent developments have important clinical implications that may lead to novel therapeutic strategies.
为了给《国际生物化学与细胞生物学杂志》关于组织修复机制的这个专题特刊奠定基础，本引言性综述简要描述了伤口愈合的过程，并着重介绍了该研究领域近期的一些关键进展。它强调了细胞间和细胞与基质相互作用的重要性，特别是与细胞表面粘附分子的作用相关，并描述了一些进展，这些进展使人们对基质周转的动态性质有了更好的理解，涉及调节前胶原基因表达和蛋白质产生的负性和正性介质。这个专题特刊的一个重要组成部分涉及组织纤维化的发展，它伴随许多疾病状态，并与正常伤口愈合过程有显著相似之处；大量基质沉积，但伤口愈合中预期的瘢痕消退受损。本文讨论了纤维化可能涉及的机制。由于细胞因子在调节细胞功能如增殖、迁移和基质合成中起重要作用，这些介质的平衡可能在调节伤口的起始、进展和消退中起关键作用。最后，本综述突出了组织修复研究的一些领域，其中近期进展具有重要的临床意义，可能会带来新的治疗策略。
