West China Biomedical Big Data Center, West China Hospital, Sichuan University, Sichuan, China.
Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, Iceland.
Elife. 2021 Jan 28;10:e63514. doi: 10.7554/eLife.63514.
Twins suffering a co-twin loss at birth have reported feelings of loneliness and grief while it remains unexplored if they suffer increased risk of psychiatric disorders. We contrasted rate of first-onset psychiatric disorders among all Swedish-born twins whose co-twin died within 60 days after birth between 1973 and 2011 (n = 787) to that of 3935 matched unexposed twins, 3935 matched singletons (both matched to the exposed twins by birth year, sex, and birth characteristics), and 880 full siblings of the exposed twins. During a median of 19-year follow-up, exposed twins were at increased risk of first-onset psychiatric disorders (hazard ratio = 1.56, 95%CI 1.30-1.87) compared with unexposed twins. We observed the strongest association for emotional disorders and for psychiatric disorders diagnosed before the age of 25. Comparisons with matched singletons and the twin's full siblings rendered similar results, corroborating an association of loss of a co-twin at birth with subsequent risk of psychiatric disorders.
出生时失去同卵双胞胎的双胞胎报告感到孤独和悲伤，而他们是否患有精神障碍的风险增加仍未得到探索。我们对比了 1973 年至 2011 年间瑞典出生的所有双胞胎的首发精神障碍发病率，这些双胞胎的同胞在出生后 60 天内死亡（n=787）与 3935 名未暴露的双胞胎、3935 名匹配的单胞胎（均通过出生年份、性别和出生特征与暴露双胞胎匹配）和暴露双胞胎的 880 名全同胞。在中位随访 19 年期间，与未暴露的双胞胎相比，暴露的双胞胎首发精神障碍的风险增加（危险比=1.56，95%CI 1.30-1.87）。我们观察到与情绪障碍和 25 岁之前诊断的精神障碍的关联最强。与匹配的单胞胎和双胞胎的全同胞进行比较得出了类似的结果，证实了出生时失去同卵双胞胎与随后的精神障碍风险之间的关联。
