Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Neurol Sci. 2021 Sep;42(9):3843-3850. doi: 10.1007/s10072-021-05074-9. Epub 2021 Jan 28.
In Egypt, circulatory system diseases are responsible for one-third of the annual deaths. Stroke comes 3rd after heart diseases and liver diseases. Stroke includes two types: ischemic and hemorrhagic. The sirtuins (SIRTs) are a family of histone deacetylases that are nicotinamide adenine dinucleotide (NAD) dependent. They are activated under conditions of decreased cellular energy stores and are involved in the control of several physiological processes.
To measure the plasma levels of SIRT1 in acute cerebrovascular stroke, to assess its role as a possible biomarker in predicting the risk of acute cerebrovascular stroke, to compare its levels between the two groups of stroke patients, and to evaluate the association between its levels and the severity of stroke. Also, to assess the correlations between the plasma SIRT1 levels and the variables that might play a role in the severity of acute cerebrovascular stroke.
This is a case-control study carried out on one hundred and eight participants. The participants were divided into two groups: group A (control group) included fifty-four individuals. Group B (acute cerebrovascular stroke group) included fifty-four stroke patients of two subgroups: B1: twenty-eight patients suffering from acute ischemic stroke and B2: twenty-six patients suffering from acute hemorrhagic stroke. Measurement of the plasma levels of SIRT1 was performed using the enzyme-linked immunosorbent assay (ELISA).
Regarding SIRT1 levels, acute stroke groups were significantly lower than the control group with no significant difference between ischemic and hemorrhagic groups. There were positive correlations between SIRT1 levels and each of the hemoglobin levels and serum potassium levels. There were negative correlations between SIRT1 levels and each of triglycerides (TG) and stroke score.
Plasma levels of SIRT1 are lower in patients with acute cerebrovascular stroke than in control. Furthermore, SIRT1 may act as a possible biomarker for predicting the risk of acute cerebrovascular stroke.
在埃及，循环系统疾病导致每年三分之一的人死亡。中风在心脏病和肝病之后位居第三。中风包括两种类型：缺血性和出血性。沉默调节蛋白（SIRTs）是一种组蛋白去乙酰化酶家族，依赖烟酰胺腺嘌呤二核苷酸（NAD）。在细胞能量储存减少的情况下，它们被激活，并参与控制几种生理过程。
测量急性脑血管病患者血浆中 SIRT1 的水平，评估其作为预测急性脑血管病风险的可能生物标志物的作用，比较两组中风患者的水平，并评估其水平与中风严重程度之间的关系。此外，评估血浆 SIRT1 水平与可能在急性脑血管病严重程度中起作用的变量之间的相关性。
这是一项病例对照研究，共纳入 108 名参与者。参与者被分为两组：A 组（对照组）包括 54 人。B 组（急性脑血管病组）包括 54 例中风患者，分为两个亚组：B1：28 例急性缺血性中风患者和 B2：26 例急性出血性中风患者。使用酶联免疫吸附试验（ELISA）测量血浆 SIRT1 水平。
急性中风组的 SIRT1 水平明显低于对照组，缺血性和出血性组之间无显著差异。SIRT1 水平与血红蛋白水平和血清钾水平呈正相关，与甘油三酯（TG）和中风评分呈负相关。
与对照组相比，急性脑血管病患者的血浆 SIRT1 水平较低。此外，SIRT1 可能作为预测急性脑血管病风险的可能生物标志物。
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