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一种用于同时检测 Cys/Hcy 和 GSH 的双信号荧光探针

A Turn-on Fluorescent Probe for the Discrimination of Cys/Hcy and GSH With Dual Emission Signals.

机构信息

Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang, Jiangxi, 330013, People's Republic of China.

出版信息

J Fluoresc. 2021 Mar;31(2):599-607. doi: 10.1007/s10895-021-02684-6. Epub 2021 Jan 28.

DOI:10.1007/s10895-021-02684-6
PMID:33507445
Abstract

In this paper, we successfully synthesized a simple and versatile fluorescent probe. This probe was not only easily prepared with a high yield, but also showed rapid selective and sensitive responses for Cys/Hcy and GSH. The probe can be used as a naked-eye detector for Cys/Hcy and GSH from other analytes. As a fluorescent sensor, it can be used to simultaneously detect and discriminate Cys/Hcy from GSH with two fluorescent emission signals without spectral crosstalk.

摘要

在本文中,我们成功合成了一种简单且通用的荧光探针。该探针不仅制备简单,产率高,而且对 Cys/Hcy 和 GSH 具有快速选择性和灵敏响应。该探针可用作其他分析物中 Cys/Hcy 和 GSH 的肉眼检测器。作为荧光传感器,它可以同时检测和区分 Cys/Hcy 和 GSH 而不会发生光谱串扰,具有两个荧光发射信号。

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引用本文的文献

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本文引用的文献

1
A multi-signal fluorescent probe for simultaneously distinguishing and sequentially sensing cysteine/homocysteine, glutathione, and hydrogen sulfide in living cells.一种用于在活细胞中同时区分和顺序检测半胱氨酸/高半胱氨酸、谷胱甘肽和硫化氢的多信号荧光探针。
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Ratiometric measurement of hydrogen sulfide and cysteine/homocysteine ratios using a dual-fluorophore fragmentation strategy.使用双荧光团裂解策略对硫化氢以及半胱氨酸/同型半胱氨酸比率进行比率测量。
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