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库拉索芦荟凝胶（巴巴多斯芦荟）对雄性 Wistar 大鼠氯化铝诱导的生殖毒性的保护作用。

Protective effects of aloe vera gel (aloe baberdensis Miller) on aluminum chloride-induced reproductive toxicity in male Wistar rats.

机构信息

Department of Human Anatomy, Federal University of Technology, Akure. Nigeria.

Department of Chemical Science, Joseph Ayo Babalola University, Ikeji-Arakeji. Nigeria.

出版信息

JBRA Assist Reprod. 2021 Apr 27;25(2):193-201. doi: 10.5935/1518-0557.20200082.

DOI:10.5935/1518-0557.20200082
PMID:33507720
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8083855/
Abstract

OBJECTIVE

This study aims at investigating the protective effects of aloe vera gel on aluminum chloride-induced testicular toxicity of adult Wistar rats.

METHODS

Twenty male Wistar rats were randomly divided into four groups (A, B, C, and D) with five animals per group. Group A serves as the control group and received distilled water (1ml/Kg). Group B received distilled water (1ml/Kg) with 100mg/kg b.wt of aluminum chloride daily. Group C received 100mg/kg b.wt of aluminum chloride with 600mg/kg b.wt of Aloe vera gel daily. Group D received 100mg/kg b.wt of aluminum chloride with 5mg/kg b.wt of vitamin C daily. The animals were fed on standard laboratory animal diet and water ad libitum. Administration was via oral cannula for four weeks. The rats were slaughtered using cervical dislocation. The testes were harvested for seminal, biochemical and histological analysis.

RESULTS

The results demonstrate that the administration of aloe vera gel (AVG) is capable of preventing testicular toxicity due to aluminum chloride. Aluminum chloride caused a significant change in the testes and seminal parameters of group B when compared to the control animals. The level of Nitric oxide (NO) increased and the level of Superoxide dismutase (SOD) decreased significantly in rats treated with aluminum chloride.

CONCLUSIONS

The administration of aloe vera gel showed a preventive response in aluminum-induced testicular toxicity of rats as evidenced by histological and biochemical analysis.

摘要

目的

本研究旨在探讨库拉索芦荟凝胶对成年 Wistar 大鼠氯化铝诱导的睾丸毒性的保护作用。

方法

将 20 只雄性 Wistar 大鼠随机分为四组（A、B、C 和 D），每组 5 只。A 组作为对照组，给予蒸馏水（1ml/Kg）。B 组给予蒸馏水（1ml/Kg）和每日 100mg/kg b.wt 的氯化铝。C 组给予每日 100mg/kg b.wt 的氯化铝和 600mg/kg b.wt 的库拉索芦荟凝胶。D 组给予每日 100mg/kg b.wt 的氯化铝和 5mg/kg b.wt 的维生素 C。动物喂食标准实验室动物饲料和水自由。通过口服套管给药四周。用颈椎脱位处死大鼠。采集睾丸进行精液、生化和组织学分析。

结果

结果表明，库拉索芦荟凝胶（AVG）的给药能够预防氯化铝引起的睾丸毒性。与对照组动物相比，氯化铝给药导致 B 组睾丸和精液参数发生显著变化。用铝处理的大鼠的一氧化氮（NO）水平升高，超氧化物歧化酶（SOD）水平显著降低。

结论

组织学和生化分析表明，库拉索芦荟凝胶的给药对大鼠铝诱导的睾丸毒性表现出预防反应。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/423a/8083855/1b4be94179d9/jbra-25-02-0193-g04.jpg
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