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Assisted reproductive technology in Japan: A summary report for 2017 by the Ethics Committee of the Japan Society of Obstetrics and Gynecology.日本的辅助生殖技术：日本妇产科学会伦理委员会2017年总结报告
Reprod Med Biol. 2019 Nov 21;19(1):3-12. doi: 10.1002/rmb2.12307. eCollection 2020 Jan.
2
Sex chromosome-dependent differential viability of human spermatozoa during prolonged incubation.长时间孵育期间人类精子的性染色体依赖性差异活力
Hum Reprod. 2017 Jun 1;32(6):1183-1191. doi: 10.1093/humrep/dex080.
3
Effect of semen quality on human sex ratio in in vitro fertilization and intracytoplasmic sperm injection: an analysis of 27,158 singleton infants born after fresh single-embryo transfer.体外受精和卵胞浆内单精子注射中精液质量对人类性别比例的影响：对新鲜单胚胎移植后出生的27158名单胎婴儿的分析。
Fertil Steril. 2016 Apr;105(4):897-904. doi: 10.1016/j.fertnstert.2015.12.009. Epub 2015 Dec 28.
4
Changes in sex ratio from fertilization to birth in assisted-reproductive-treatment cycles.辅助生殖治疗周期中从受精到出生的性别比例变化。
Reprod Biol Endocrinol. 2014 Jun 23;12:56. doi: 10.1186/1477-7827-12-56.
5
Effects of assisted reproductive technologies on human sex ratio at birth.辅助生殖技术对人类出生性别比的影响。
Fertil Steril. 2014 May;101(5):1321-5. doi: 10.1016/j.fertnstert.2014.01.041. Epub 2014 Mar 3.
6
Gender incidence of intracytoplasmic morphologically selected sperm injection-derived embryos: a prospective randomized study.经形态学选择的胞质内精子注射衍生胚胎的性别发生率：一项前瞻性随机研究。
Reprod Biomed Online. 2012 Apr;24(4):420-3. doi: 10.1016/j.rbmo.2012.01.007. Epub 2012 Jan 24.
7
The effect on human sex ratio at birth by assisted reproductive technology (ART) procedures--an assessment of babies born following single embryo transfers, Australia and New Zealand, 2002-2006.ART 程序对人类出生性别比的影响——对澳大利亚和新西兰 2002-2006 年单胚胎移植后出生婴儿的评估。
BJOG. 2010 Dec;117(13):1628-34. doi: 10.1111/j.1471-0528.2010.02731.x. Epub 2010 Sep 28.
8
Blastocyst transfer and gender: IVF versus ICSI.囊胚移植与性别：体外受精与卵胞浆内单精子注射
J Assist Reprod Genet. 2009 Aug;26(8):433-6. doi: 10.1007/s10815-009-9337-3.
9
The sex ratio of singleton offspring in assisted-conception pregnancies.辅助受孕妊娠中单胎后代的性别比例。
Fertil Steril. 2009 Nov;92(5):1579-85. doi: 10.1016/j.fertnstert.2008.08.107. Epub 2008 Oct 31.
10
Differential sensitivity of male and female mouse embryos to oxidative induced heat-stress is mediated by glucose-6-phosphate dehydrogenase gene expression.雄性和雌性小鼠胚胎对氧化诱导热应激的差异敏感性由葡萄糖-6-磷酸脱氢酶基因表达介导。
Mol Reprod Dev. 2005 Dec;72(4):502-10. doi: 10.1002/mrd.20366.

体外受精和胚胎移植所产婴儿的性别比例：单中心研究结果及文献复习。

Sex ratio of infants born through in vitro fertilization and embryo transfer: Results of a single-institution study and literature review.

机构信息

Department of Obstetrics and Gynecology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan.

出版信息

JBRA Assist Reprod. 2021 Jul 21;25(3):337-340. doi: 10.5935/1518-0557.20200096.

DOI:10.5935/1518-0557.20200096
PMID:33507723
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8312283/
Abstract

OBJECTIVE

The possible effects of Assisted Reproductive Technology (ART) on sex ratio at birth are extremely significant. This study aimed to determine whether ART affects the sex ratio of infants born through in vitro fertilization and embryo transfer (IVF-ET).

MATERIALS AND METHODS

We ran this retrospective study on 290 singleton infants born following IVF-ET from February 2014 to August 2018 at a single institution. We compared the sex ratios of these infants with respect to insemination versus intracytoplasmic sperm injection (ICSI), early-cleavage embryo versus blastocyst transfer, fresh versus frozen-thawed embryo transfer and normal sperm versus asthenospermia.

RESULTS

There were no significant differences in the sex ratio with respect to the fertilization method, transfer time, fresh embryo or frozen-thawed embryo transfer. In addition, the multiple logistic regression analysis revealed that these factors did not significantly affect the sex ratio.

CONCLUSIONS

Our study indicated that the differences in the fertilization method transfer time and sperm motility rate did not affect the sex ratio of IVF live births. However, with increasing numbers of ICSI and blastocyst transfer cycles, factors possibly affecting the sex ratio need to be further investigated.

摘要

目的

辅助生殖技术（ART）对出生性别比的可能影响极其显著。本研究旨在确定体外受精和胚胎移植（IVF-ET）是否会影响婴儿的性别比例。

材料与方法

我们对 2014 年 2 月至 2018 年 8 月在一家机构进行的 290 例 IVF-ET 单胎婴儿进行了回顾性研究。我们比较了这些婴儿的性别比例，涉及受精方式（常规受精与卵胞浆内单精子注射（ICSI））、胚胎移植时间（卵裂期胚胎与囊胚）、新鲜胚胎与冷冻解冻胚胎移植，以及正常精子与弱精症精子。

结果

受精方式、胚胎移植时间、新鲜胚胎或冷冻解冻胚胎移植与性别比例均无显著差异。此外，多因素逻辑回归分析表明，这些因素对性别比例无显著影响。

结论

本研究表明，受精方式、胚胎移植时间和精子活力的差异并不影响 IVF 活产儿的性别比例。然而，随着 ICSI 和囊胚移植周期的增加，可能影响性别比例的因素需要进一步研究。